| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 627 | Alex Huston | Glendale | Camdenton | 10/16/2015 | |
| 2 | 574 | Austin Jones | Orrick | Windsor | 10/3/2003 | 522 rush, 52 PR |
| 3 | 522 | Jake Harlan | St. James | Owensville | 10/27/2011 | |
| 4 | 508 | Blane Boss | Windsor (Imperial) | Hillsboro | 9/19/2003 | |
| 5 | 504 | Austin Jones | Orrick | Windsor | 9/28/2001 | |
| 6 | 502 | Paris Tipler | East Prairie | Liberty (Mountain View) | 9/9/2005 | |
| 7 | 483 | Chad Shockley | St. James | Southern Boone | 10/14/2005 | |
| 8 | 480 | Kellen Overstreet | Penney | Polo | 11/7/2014 | |
| 9 | 465 | Andrew Graves | Jefferson (Festus) | St. Vincent | 10/16/2015 | |
| 10 | 457 | Preston Hatfield | Lee's Summit | Lee's Summit | 12/6/2025 | Class 6 |
| 11 | 454 | Bryce Enyard | Westran | Paris | 9/11/2009 | |
| 11 | 454 | Trevor Meyer | West Nodaway | Tarkio | 9/5/2014 | |
| 11 | 454 | Enrique Padron | Missouri Military Academy | Crystal City | 10/16/2020 | |
| 14 | 419 | Ezekiel Elliott | John Burroughs | Maryville | 11/23/2012 | |
| 15 | 365 | Derrick Washington | Raymore-Peculiar | Kirkwood | 11/25/2006 | |
| 16 | 345 | Kyren Williams | Vianney | Fort Osage | 12/1/2018 | Class 5 |
| 17 | 339 | Leroy Pruitt | Blue Springs | Parkway Central | 11/28/1992 | |
| 18 | 318 | Jeremiyah Love | Christian Brothers College | Lee's Summit North | 11/26/2022 | Class 6 |
| 19 | 316 | Lee Flood | Marionville | West Platte | 11/26/2005 | |
| 20 | 308 | Ethan Harris | South Shelby | Marionville | 11/25/2006 | |