| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 715 | | Lebanon | Parkview | 10/17/2017 | |
| 2 | 707 | | Hermann | Union | 10/16/2015 | |
| 3 | 693 | | Sherwood | Maranatha Academy (KS) | 9/19/2008 | |
| 4 | 664 | | Republic | Glendale | 10/30/2015 | |
| 5 | 641 | | Ft. Zumwalt North | Warrenton | 9/9/2011 | |
| 6 | 630 | | Salem | Cabool | 9/22/2000 | |
| 7 | 624 | | Wright City | Clopton | 9/4/2010 | |
| 8 | 622 | | Chaffee | Veritas Christian HS | 10/11/2024 | |
| 9 | 621 | | Ft. Zumwalt North | St. Charles | 9/2/2011 | |
| 10 | 617 | | Richmond | Knob Noster | 10/20/2000 | |
| 11 | 616 | | Helias Catholic | Moberly | 9/25/1983 | |
| 12 | 611 | | Ritenour | Parkway North | 9/22/2017 | |
| 12 | 611 | | Excelsior Springs | | 9/21/2018 | Harrisonville |
| 14 | 604 | | Troy Buchanan | Troy Buchanan | 9/28/2018 | |
| 15 | 603 | | Jefferson (Festus) | St. Vincent | 10/16/2015 | |
| 16 | 592 | | Lebanon | Glendale | 9/14/2018 | |
| 17 | 570 | | Lebanon | Union | 11/1/2019 | |
| 18 | 549 | | West Plains | Waynesville | 10/7/2011 | |
| 19 | 527 | | Maryville | | 9/3/1999 | |
| 19 | 527 | | Lebanon | Willard | 11/6/2020 | |
| 21 | 520 | | Lebanon | Waynesville | 9/18/2020 | |
| 22 | 518 | | Lamar | Lawson | 11/29/2013 | |
| 23 | 515 | | Sweet Springs | | 9/13/2019 | |
| 24 | 514 | | Crest Ridge | Wellington-Napoleon | 9/1/2023 | |
| 25 | 507 | | Lebanon | Waynesville | 9/16/2011 | |
| 25 | 507 | | Schuyler County | | 9/27/2019 | |
| 27 | 503 | | Lamar | Blair Oaks | 11/24/2012 | |
| 28 | 501 | | Priory | West Platte | 12/1/1973 | |
| 29 | 500 | | Excelsior Springs | | 10/19/2018 | Pleasant Hill |
| 29 | 500 | | Lebanon | Glendale | 9/20/2019 | |
| 31 | 499 | | Excelsior Springs | | 10/5/2018 | Oak Grove |
| 32 | 491 | | Excelsior Springs | | 10/26/2018 | |
| 33 | 488 | | Chaffee | Doniphan | 10/14/2022 | |
| 33 | 488 | | Warsaw | Buffalo | 10/21/2022 | |
| 35 | 487 | | Lebanon | Parkview | 10/14/2016 | |
| 36 | 485 | | Mound City | Southwest (Livingston County) | 11/30/2019 | 8-Man |
| 37 | 478 | | Webb City | MICDS | 11/25/2011 | |
| 38 | 473 | | Lebanon | Branson | 10/27/2017 | |
| 39 | 457 | | Lebanon | Waynesville | 8/25/2017 | |
| 40 | 454 | | Lebanon | Rolla | 10/16/2020 | |
| 41 | 452 | | North Andrew | Bishop LeBlond | 12/1/2022 | 8-Man |
| 42 | 441 | | Ft. Zumwalt North | | 8/26/2011 | vs. Duchesne HS |
| 42 | 441 | | Excelsior Springs | | 9/14/2018 | Richmond |
| 44 | 436 | | Maryville | John Burroughs | 11/23/2012 | |
| 45 | 418 | | North Andrew | Fairfax | 11/1/1996 | |
| 45 | 418 | | North Andrew | Fairfax | 11/23/1996 | 8-Man |
| 47 | 404 | | Ft. Zumwalt North | | 9/27/2019 | |
| 48 | 400 | | Mound City | North Andrew | 11/1/1999 | |