| Rank | Student | School | Years | | G | AST |
| 1 | Kelly Walden | Rich Hill | 1985-1988 | | 117 | 959 |
| 2 | Kelley Meier | Parkway North | 1985-1987 | | 83 | 942 |
| 3 | Kim Woodruff | St. James | 1994-1997 | | 115 | 937 |
| 4 | Alexis Uffmann | St. James | 2011-2014 | | 30 | 845 |
| 5 | Kenna Rae Walker | New Bloomfield | 1986-1989 | | 120 | 844 |
| 6 | Michelle McQueen | Lutheran South | 2004-2007 | | 116 | 794 |
| 7 | Jennifer Bowen | St. James | 2002-2005 | | 119 | 791 |
| 8 | Mikal Bencomo | Clopton | 2003-2006 | | 126 | 790 |
| 9 | Heather R Harman | Walnut Grove | 2010-2013 | | 125 | 758 |
| 10 | Julie McQueen | Lutheran South | 2001-2004 | | 115 | 716 |
| 11 | Jill Bybee | Skyline | 2001-2004 | | 121 | 689 |
| 12 | Jayme Callahan | Rosary | 1995-1998 | | 115 | 663 |
| 13 | Angela Scott | Thomas Jefferson Independent | 2002-2005 | | 101 | 619 |
| 14 | Jade Berry | Delta | 2021-2024 | | 118 | 592 |
| 15 | Allie Heckemeyer | St. Elizabeth | 2010-2014 | | 109 | 587 |
| 16 | Becky Martin | Warren County | 1987-1989 | | 80 | 583 |
| 17 | Madison Rae Ayers | South Iron | 2019-2022 | | 113 | 573 |
| 18 | Brooklyn Duggan | Macks Creek | 2021-2024 | | 103 | 567 |
| 19 | Kelsi McQuinn | Jefferson (Conception) | 2013-2016 | | 116 | 548 |
| 20 | Madison Carvajal | Tipton | 2022-2025 | | 118 | 538 |
| 21 | Myra Claas | Tipton | 2019-2022 | | 125 | 526 |
| 22 | Sheridan Corum | Hermitage | 2014-2018 | | 111 | 476 |
| 23 | Lacy Stokes | Mt. Vernon | 2017-2020 | | 122 | 473 |
| 24 | Taylor Cook | Lesterville | 2008-2012 | | 95 | 451 |
| 24 | Carlie Sanders | Hillsboro | 2014-2017 | | 103 | 451 |
| 26 | Brooklyn Shaye Luna | Fair Grove | 2017-2020 | | 89 | 423 |
| 27 | Paidyn Linville | West Nodaway | 2021-2024 | | 109 | 417 |
| 28 | Korrie Holcer | Meadville | 2020-2023 | | 107 | 413 |
| 29 | Payton Curley | Salem | 2013-2016 | | 103 | 407 |
| 30 | Marley A Winkler | Northeast (Cairo) | 2012-2016 | | 113 | 403 |