| Rank | Student | School | Years | | Pts | G | PPG |
| 1 | Paul Werle | Orrick | 1986-1988 | | 2522 | 73 | 34.55 |
| 2 | Aminu Mohammed | Greenwood | 2018-2020 | | 2709 | 87 | 31.14 |
| 3 | Fred Johnson | Wellsville-Middletown | 1983-1986 | | 3552 | 120 | 29.60 |
| 4 | Brad Hocker | Archie | 1989-1992 | | 3038 | 104 | 29.21 |
| 5 | Barry Laurie | Versailles | 1975-1978 | | 2980 | 105 | 28.38 |
| 6 | Kenny King | Bucklin | 1979-1981 | | 2211 | 79 | 27.99 |
| 7 | Jon Sundvold | Blue Springs | 1977-1979 | | 2175 | 79 | 27.53 |
| 8 | Bill Roundtree | Wellsville-Middletown | 1979-1982 | | 3243 | 118 | 27.48 |
| 9 | Percy Wells | Central (St. Louis) | 1969-1972 | | 1923 | 70 | 27.47 |
| 10 | Bill Bradley | Crystal City | 1958-1961 | | 3068 | 112 | 27.39 |
| 11 | Daniel Cutbirth | Hurley | 1995-1998 | | 2958 | 108 | 27.39 |
| 12 | Ryder Joseph Williams | Versailles | 2020-2023 | | 2877 | 108 | 26.64 |
| 13 | Tony Osburn | Mound City | 2018-2021 | | 3080 | 116 | 26.55 |
| 14 | Michael Isaia Howard | Plattsburg | 2020-2023 | | 3001 | 114 | 26.32 |
| 15 | Adam Stanley | Princeton | 1989-1993 | | 2751 | 107 | 25.71 |
| 16 | Jay Lee | Glasgow | 2005-2009 | | 2999 | 119 | 25.20 |
| 17 | Stump, Arlo | Golden City | 2016-2020 | | 2734 | 112 | 24.41 |
| 18 | Daniel Presley | Risco | 1996-1999 | | 2078 | 90 | 23.09 |
| 19 | Jordan Fuemmeler | Glasgow | 2020-2023 | | 2571 | 112 | 22.96 |
| 20 | Casey Knight | Risco | 1995-1998 | | 1740 | 76 | 22.89 |
| 21 | Logan Thomazin | Walnut Grove | 2014-2017 | | 2891 | 127 | 22.76 |
| 22 | Drenin Dinkins | South Iron | 2018-2021 | | 2646 | 118 | 22.42 |
| 23 | Carter Trumbore | Butler | 2020-2023 | | 2382 | 107 | 22.26 |
| 23 | Carter Trumbore | Butler | 2020-2023 | | 2382 | 107 | 22.26 |
| 25 | Andrew Dalton | Ava | 2018-2021 | | 2431 | 111 | 21.90 |
| 26 | Lane Duncan | Licking | 2011-2014 | | 2441 | 112 | 21.79 |
| 27 | Blake Fowler | Campbell | 2017-2020 | | 2345 | 108 | 21.71 |
| 28 | Dale Stanley | Licking | 1964-1967 | | 2494 | 118 | 21.14 |
| 29 | Kiefer Tolson | Trenton | 2021-2024 | | 2043 | 97 | 21.06 |
| 30 | Benjamin M Denbow | Licking | 2008-2012 | | 2392 | 114 | 20.98 |
| 30 | Benjamin M Denbow | Licking | 2008-2012 | | 2392 | 114 | 20.98 |
| 32 | Sam Richardson Jr. | Hancock | 2016-2019 | | 2176 | 104 | 20.92 |
| 33 | Drew Apsher | Smithton | 2013-2016 | | 2130 | 104 | 20.48 |
| 34 | Jon Samuel Smith | Risco | 2021-2024 | | 1942 | 95 | 20.44 |
| 35 | Michael Russell | McDonald County | 1994-1997 | | 2065 | 104 | 19.86 |
| 36 | Rafe Kalberloh | Lakeland | 2017-2021 | | 2237 | 113 | 19.80 |
| 37 | Luke Northweather | Blair Oaks | 2018-2021 | | 2018 | 102 | 19.78 |
| 38 | Nathan Burnett | Risco | 2015-2018 | | 2109 | 107 | 19.71 |
| 39 | Brock Wakefield | South Iron | 2017-2020 | | 2068 | 106 | 19.51 |
| 40 | Caleb Coen Brown | Sacred Heart | 2018-2021 | | 2105 | 109 | 19.31 |
| 41 | Clayton Parker | Montgomery County | 2021-2024 | | 2281 | 119 | 19.17 |
| 42 | Trent Smith | Carl Junction | 2015-2018 | | 1829 | 97 | 18.86 |
| 43 | Corbin Joe Axtell | Grundy County | 2020-2024 | | 2073 | 110 | 18.85 |
| 44 | Chase Parrish | Montgomery County | 2013-2016 | | 2054 | 109 | 18.84 |
| 45 | Jacob Richard Elmore-Stellwagen | Montgomery County | 2020-2023 | | 2046 | 111 | 18.43 |
| 46 | Lane Dunlap | Golden City | 2017-2020 | | 2068 | 113 | 18.30 |
| 47 | Isaac Bird | Gallatin | 2020-2023 | | 1948 | 107 | 18.21 |
| 48 | Jackson Meyer | Glasgow | 2025-2026 | | 2039 | 113 | 18.04 |
| 49 | Andrew Almany | Licking | 2000-2003 | | 1885 | 106 | 17.78 |
| 50 | Gage Johnson | Weaubleau | 2020-2023 | | 1997 | 117 | 17.07 |
| 51 | Trenton Lyles | Sacred Heart | 2014-2017 | | 2007 | 118 | 17.01 |
| 52 | Trenton Jameson McBride | Eminence | 2015-2019 | | 2036 | 120 | 16.97 |
| 53 | Jordon Pavy | Risco | 2010-2013 | | 1786 | 108 | 16.54 |