| Rank | Student | Grade | School | Year | | W | L |
| 1 | Jeffnani Elsmarie Denopol | Sr | North Kansas City | 2025 | | 39 | 2 |
| 2 | Anna Rader | Sr | Springfield Catholic | 2017 | | 38 | 2 |
| 3 | Sydney Fuger | So | North Kansas City | 2022 | | 37 | 1 |
| 4 | Melissa Hoffmeister | Sr | Joplin | 2005 | | 35 | 1 |
| 4 | Olivia Lee McGruder | Sr | Lebanon | 2024 | | 35 | 6 |
| 6 | Colleen Rielley | Fr | St. Teresa's Academy | 2002 | | 34 | 2 |
| 6 | Erin Jarvis | So | Springfield Catholic | 2018 | | 34 | 3 |
| 8 | Stephanie Smarr | Fr | Rock Bridge | 2000 | | 33 | 6 |
| 9 | Kristin Kornegay | Jr | Rock Bridge | 2001 | | 32 | 2 |
| 9 | Merritt Whitley | So | Park Hill | 2007 | | 32 | 3 |
| 9 | Erin Jarvis | Jr | Springfield Catholic | 2019 | | 32 | 3 |
| 9 | Stephanie Werthmuller | Jr | Park Hill | 1998 | | 32 | 5 |
| 13 | Melissa Hoffmeister | Fr | Joplin | 2002 | | 31 | 2 |
| 13 | Susan Ma | Jr | Park Hill South | 2005 | | 31 | 2 |
| 13 | Victoria Wever | Sr | Rolla | 2006 | | 31 | 2 |
| 13 | Katie Friedlund | Jr | Park Hill South | 2005 | | 31 | 3 |
| 13 | Katie Friedlund | Fr | Park Hill South | 2003 | | 31 | 4 |
| 18 | Jane Dickinson | Sr | Chillicothe | 1992 | | 29 | 0 |
| 19 | Kara Hickey | Fr | Rock Bridge | 2001 | | 26 | 1 |
| 20 | Zaylee Rose | Jr | Columbia Independent | 2024 | | 23 | 1 |
| 20 | Lila Griesemer | Jr | Springfield Catholic | 2023 | | 23 | 4 |
| 20 | Kaylyn Seals | Jr | Odessa | 2025 | | 23 | 9 |
| 23 | Caroline Nelson | Sr | Springfield Catholic | 2023 | | 22 | 3 |
| 24 | Hannah Marie Helvey | Sr | Arcadia Valley | 2020 | | 21 | 1 |
| 24 | Grace Dow | Sr | Lebanon | 2016 | | 21 | 3 |
| 24 | Abigail Louise Overbay | Sr | Harrisonville | 2022 | | 21 | 3 |
| 27 | Michelle Kedzierski | Fr | St. Joseph's Academy | 2006 | | 20 | 1 |
| 27 | Alex A Lehman | Jr | John Burroughs | 2007 | | 20 | 1 |
| 27 | Lillian Hopson | Sr | Harrisonville | 2024 | | 20 | 1 |
| 27 | Dannie Wilson | So | Mt. Vernon | 2016 | | 20 | 3 |
| 27 | Kelsey Cockrum | Jr | Odessa | 2019 | | 20 | 7 |
| 32 | Madison Gray | Sr | Festus | 2025 | | 19 | 5 |
| 33 | Abigail Haley | Sr | Saxony Lutheran | 2024 | | 15 | 3 |
| 33 | Clara Lincoln | Jr | Festus | 2025 | | 15 | 6 |
| 35 | Ava Marie Lee | Sr | Festus | 2025 | | 12 | 7 |
| 35 | Grace Vogel | Jr | Festus | 2025 | | 12 | 7 |
| 37 | Margaret Hillin | Jr | Saxony Lutheran | 2023 | | 11 | 4 |