| Rank | Time | Student | Grade | School | Year | |
| 1 | 17:12.70 |
Natalie Barnard
Lafayette (Wildwood) | 2023
| Sr | Lafayette (Wildwood) | 2023 | Class 5 |
| 2 | 17:14.22 |
Taylor Werner
Ste. Genevieve | 2015
| Sr | Ste. Genevieve | 2015 | Class 3 |
| 3 | 17:31.30 |
Taylor Werner
Ste. Genevieve | 2013
| So | Ste. Genevieve | 2013 | Class 3 |
| 4 | 17:34.10 |
Brianna Krueger
St. Charles West | 2026
| Sr | St. Charles West | 2026 | Class 3 |
| 5 | 17:35.40 |
Anna Ross
Reeds Spring | 2026
| Fr | Reeds Spring | 2026 | Class 3 |