| Rank | Time | Student | Grade | School | Year | |
| 1 | 20.96 | Maurice Mitchell | | Raytown South | 2007 | |
| 2 | 21.04 | Domenik Peterson | | Jefferson City | 2003 | |
| 2 | 21.04 | Paul Chaney | | St. Louis University | 2006 | |
| 4 | 21.12 | Naron Williams | | Platte County | 2012 | |
| 5 | 21.14 | Mario Whitney | | Jackson | 2002 | 20.9 handheld |
| 6 | 21.32 | Ryan Hooker | | Hickman Mills High School | 1999 | Class 3 |
| 7 | 21.39 | Jayson Ashford | | St. Louis University | 2016 | Class 5 |
| 8 | 21.40 | Herbert Johnson | | Fulton | 1981 | Class 3 |
| 9 | 21.56 | Micah Beaver | | Raymore-Peculiar | 2016 | Class 5 |
| 10 | 21.57 | Isaiah Cole | | Hazelwood West | 2016 | Class 5 |
| 11 | 21.65 | Kelvin Michael Wells | | Cleveland NJROTC | 2014 | Class 2 |
| 12 | 21.87 | Fred Taylor | | Maplewood-Richmond Hts. | 2009 | Class 2 |
| 12 | 21.87 | Antonio Marcano | | Metro | 2012 | Class 2 |
| 14 | 22.15 | Larry Rogers | | Missouri School for the Deaf | 1980 | Class 1 |
| 15 | 22.36 | Michael Null | | Braymer | 1995 | Class 1 |
| 16 | 22.40 | Mitchell Officer | | North Andrew | 2016 | Class 1 |
| 17 | 33:22.00 | Mario Whitney | | Jackson | 2002 | (20.9h) |