| Rank | Total | Student | School | Opponent | Date | |
| 1 | -91 | | King City | Pattonsburg | 9/17/2021 | |
| 2 | -66 | | St. Louis University | McCluer | 9/22/1967 | |
| 3 | -63 | | Rich Hill | Archie | 9/6/1994 | |
| 4 | -59 | | Windsor | Crest Ridge | 10/13/2023 | |
| 5 | -55 | | Helias Catholic | Mercy (St. Louis) | 10/3/1979 | |
| 6 | -53 | | Hardin-Central | Wentworth Military Academy | 10/1/1999 | |
| 7 | -52 | | Westran | Salisbury | 8/28/2020 | |
| 8 | -37 | | Chillicothe | Macon | 9/29/1950 | |
| 9 | -35 | | St. Louis University | Normandy Collaborative | 9/22/1939 | |
| 10 | -33 | | Pattonville | Normandy Collaborative | 10/25/1997 | |
| 10 | -33 | | Parkway North | Central (Cape Girardeau) | 8/27/2009 | |
| 12 | -32 | | Hillsboro | DeSoto | 10/19/2001 | |
| 13 | -27 | | Blue Springs | Hazelwood East | 11/23/2001 | |
| 14 | -25 | | Liberty North | Liberty | 9/1/2023 | |
| 15 | -24 | | North Shelby | Schuyler County | 9/17/2021 | |
| 16 | -9 | | Crest Ridge | Lincoln | 9/8/2023 | |
| 17 | -8 | | North Andrew | South Holt | 11/1/1997 | |
| 18 | -6 | | Warrensburg | Fairfax | 11/25/1972 | |
| 19 | -5 | | Jefferson City | Hazelwood Central | 11/25/1978 | |
| 19 | -5 | | Francis Howell North | Ft. Zumwalt South | 10/15/2021 | |
| 21 | -4 | | Lamar | St. Pius X (Kansas City) | 12/4/2020 | |
| 22 | 0 | | Jefferson City | Mehlville | 11/26/1994 | |
| 23 | 5 | | Joplin | DeSmet | 11/29/1975 | |