| Rank | Student | School | Years | | AST | Sets | Total |
| 1 | Sarah Mueller | Santa Fe | 1994-1997 | | 2515 | 191 | 13.17 |
| 2 | Carley Nicholson | St. Pius X (Festus) | 2014-2017 | | 3722 | 328 | 11.35 |
| 3 | Natalie Emro | Lafayette (Wildwood) | 2005-2006 | | 1496 | 143 | 10.46 |
| 4 | Erin McClanahan | Cor Jesu Academy | 1999-2001 | | 1954 | 188 | 10.39 |
| 5 | Jenny Orf | Lafayette (Wildwood) | 2000-2003 | | 2834 | 290 | 9.77 |
| 6 | Olivia Lotz | Timberland | 2014-2017 | | 2759 | 292 | 9.45 |
| 7 | Sophie Whitesell | Lockwood | 2005-2008 | | 2801 | 302 | 9.27 |
| 8 | Alexa Ethridge | Lee's Summit North | 2005 | | 2973 | 321 | 9.26 |
| 9 | Maggie Scott | Lafayette (Wildwood) | 2011-2013 | | 2279 | 249 | 9.15 |
| 10 | Amy Lindhorst | Oak Park | 2009-2012 | | 2633 | 298 | 8.84 |
| 11 | Shannon Ayer | Notre Dame de Sion | 1999-2002 | | 2728 | 314 | 8.69 |
| 12 | Katie Hyneman | Oak Park | 2005-2006 | | 1235 | 147 | 8.40 |
| 13 | Hannah Nicole Vaughn | Poplar Bluff | 2015-2017 | | 1809 | 224 | 8.08 |
| 14 | Taryn Nash | Truman | 2006-2009 | | 2425 | 309 | 7.85 |
| 15 | Erin Moore | Bernie | 1992-1995 | | 2366 | 307 | 7.71 |
| 16 | Lexie Malam | Houston | 2003-2006 | | 1623 | 217 | 7.48 |
| 17 | Bethanie Nicole Funderburk | Nixa | 2006-2009 | 3 Years | 1206 | 163 | 7.40 |
| 18 | Kenna O'Riley | Bishop LeBlond | 2016-2019 | | 2260 | 312 | 7.24 |
| 19 | Kendra N Sater | Ozark | 2012-2015 | | 2501 | 364 | 6.87 |
| 20 | Bailey Myers | Lesterville | 2014-2017 | | 2002 | 292 | 6.86 |
| 21 | Tedi Thoreson | El Dorado Springs | 1999-2002 | | 1913 | 293 | 6.53 |
| 22 | Ashley Hydorn | Oak Park | 1999-2002 | | 1955 | 302 | 6.47 |
| 23 | Madeline Yahnig | Midway | 2015-2018 | | 1784 | 283 | 6.30 |