| Rank | Student | School | Years | | K | Sets | Total |
| 1 | Tessa Jones | O'Hara | 2000-2003 | | 1908 | 311 | 6.14 |
| 2 | Katie Panhorst | St. Charles | 1993-1995 | | 957 | 158 | 6.06 |
| 3 | Kristin Folkl | St. Joseph's Academy | 1990-1993 | | 1819 | 306 | 5.94 |
| 4 | Taylor Cook | Lesterville | 2008-2011 | | 1484 | 266 | 5.58 |
| 5 | Maddie DeMent | Arcadia Valley | 2017-2020 | | 1537 | 296 | 5.19 |
| 6 | Jamie Roszell | East Newton | 1995-1998 | | 1303 | 251 | 5.19 |
| 7 | Christi Myers | Raytown South | 1995-1998 | | 1399 | 274 | 5.11 |
| 8 | Marissa Hundelt | Orchard Farm | 2006-2009 | | 1165 | 230 | 5.07 |
| 9 | Kaitlyn M. Creek | Stockton | 2016-2019 | | 1265 | 256 | 4.94 |
| 10 | Tera Reberry | Pleasant Hill | 2017-2020 | | 1180 | 247 | 4.78 |
| 11 | Julie Williams | St. Charles | 1992-1994 | | 765 | 164 | 4.66 |
| 12 | Mallory Polk | Lesterville | 2017-2020 | | 1574 | 338 | 4.66 |
| 13 | Lauren Standlee | Thomas Jefferson Independent | 1997-2000 | | 1208 | 263 | 4.59 |
| 14 | Autumn Craft | Verona | 1995-1998 | | 1401 | 310 | 4.52 |
| 15 | Rebekah Wedick | Willow Springs | 1996-1999 | | 1123 | 253 | 4.44 |
| 16 | Kara Schilli | Valle Catholic | 2001-2004 | | 1190 | 271 | 4.39 |
| 17 | Marianne Elizab Beal | Lee's Summit North | 2006-2009 | | 1330 | 303 | 4.39 |
| 18 | Aubrey Cheffey | Nixa | 2012-2015 | | 1168 | 269 | 4.34 |
| 19 | Cameron Layne Dake | Mt. Vernon | 2012-2015 | | 1190 | 284 | 4.19 |
| 19 | Cameron Layne Dake | Mt. Vernon | 2012-2015 | | 1190 | 284 | 4.19 |
| 21 | Amelia Flynn | Timberland | 2014-2017 | | 1045 | 250 | 4.18 |
| 22 | Morgan N. Beal | Lee's Summit North | 2009-2012 | | 1239 | 319 | 3.88 |
| 23 | Salma Lewis | Carl Junction | 2017-2020 | Career kills | 1227 | 327 | 3.75 |
| 24 | Lily Johnson | Lafayette (Wildwood) | 2010-2013 | | 974 | 264 | 3.69 |
| 25 | Ryenne Olivia Gepford | Butler | 2017-2020 | | 1000 | 281 | 3.56 |
| 26 | Lisa Downey | Lafayette (Wildwood) | 1998-2000 | | 1030 | 295 | 3.49 |
| 27 | Jaycee Theo Fixsen | Nixa | 2018-2021 | | 1191 | 369 | 3.23 |
| 28 | Makenna Irvin | Midway | 2014-2017 | | 877 | 273 | 3.21 |
| 29 | Alyxandra Marie Gepford | Butler | 2010-2013 | | 901 | 282 | 3.20 |
| 30 | Regan Michele Peltier | Nixa | 2008-2011 | | 980 | 313 | 3.13 |