| Rank | Student | School | Years | | Sets | Total |
| 1 | Tessa Jones | O'Hara | 2000-2003 | | 311 | 1908 |
| 2 | Rachel Holthaus | Winona | 2011-2014 | | | 1873 |
| 3 | Kristin Folkl | St. Joseph's Academy | 1990-1993 | | 306 | 1819 |
| 4 | Mallory Polk | Lesterville | 2017-2020 | | 338 | 1574 |
| 5 | Maddie DeMent | Arcadia Valley | 2017-2020 | | 296 | 1537 |
| 6 | Taylor Cook | Lesterville | 2008-2011 | | 266 | 1484 |
| 7 | Autumn Craft | Verona | 1995-1998 | | 310 | 1401 |
| 8 | Christi Myers | Raytown South | 1995-1998 | | 274 | 1399 |
| 9 | Marianne Beal | Lee's Summit North | 2006-2009 | | 303 | 1330 |
| 9 | Marianne Elizab Beal | Lee's Summit North | 2006-2009 | | 303 | 1330 |
| 11 | Jamie Roszell | East Newton | 1995-1998 | | 251 | 1303 |
| 12 | Kaitlyn M. Creek | Stockton | 2016-2019 | | 256 | 1265 |
| 13 | Morgan Beal | Lee's Summit North | 2009-2012 | | 319 | 1239 |
| 13 | Morgan N. Beal | Lee's Summit North | 2009-2012 | | 319 | 1239 |
| 15 | Salma Lewis | Carl Junction | 2017-2020 | Career kills | 327 | 1227 |
| 16 | Lauren Standlee | Thomas Jefferson Independent | 1997-2000 | | 263 | 1208 |
| 17 | Jaycee Theo Fixsen | Nixa | 2018-2021 | | 369 | 1191 |
| 18 | Kara Schilli | Valle Catholic | 2001-2004 | | 271 | 1190 |
| 18 | Cameron Layne Dake | Mt. Vernon | 2012-2015 | | 284 | 1190 |
| 20 | Tera Reberry | Pleasant Hill | 2017-2020 | | 247 | 1180 |
| 21 | Aubrey Cheffey | Nixa | 2012-2015 | | 269 | 1168 |
| 22 | Marissa Hundelt | Orchard Farm | 2006-2009 | | 230 | 1165 |
| 23 | Rebekah Wedick | Willow Springs | 1996-1999 | | 253 | 1123 |
| 24 | Amelia Flynn | Timberland | 2014-2017 | | 250 | 1045 |
| 25 | Lisa Downey | Lafayette (Wildwood) | 1998-2000 | | 295 | 1030 |
| 26 | Ryenne Olivia Gepford | Butler | 2017-2020 | | 281 | 1000 |
| 27 | Regan Michele Peltier | Nixa | 2008-2011 | | 313 | 980 |
| 28 | Lily Johnson | Lafayette (Wildwood) | 2010-2013 | | 264 | 974 |
| 29 | Katie Panhorst | St. Charles | 1993-1995 | | 158 | 957 |
| 30 | Alyxandra Marie Gepford | Butler | 2010-2013 | | 282 | 901 |
| 31 | Makenna Irvin | Midway | 2014-2017 | | 273 | 877 |
| 32 | Julie Williams | St. Charles | 1992-1994 | | 164 | 765 |