| Rank | Student | School | Years | | Sets | K |
| 1 | | Mountain Grove | 2021-2024 | | 360 | 2337 |
| 2 | Reagan R Nelson | Pattonville | 2021-2024 | | 402 | 2143 |
| 3 | Reese Gray | Lesterville | 2019-2022 | | 382 | 2056 |
| 4 | Tessa Jones | O'Hara | 2000-2003 | | 311 | 1908 |
| 5 | Rachel Holthaus | Winona | 2011-2014 | | | 1873 |
| 6 | Kristin Folkl | St. Joseph's Academy | 1990-1993 | | 306 | 1819 |
| 7 | Emma Siron | Sacred Heart | 2019-2022 | | 326 | 1737 |
| 8 | Summer Kenney | Stockton | 2019-2023 | Career Kills | 347 | 1646 |
| 9 | Mallory Polk | Lesterville | 2017-2020 | | 338 | 1574 |
| 10 | Maddie DeMent | Arcadia Valley | 2017-2020 | | 296 | 1537 |
| 11 | Nevaeh Malawey | Winona | 2019-2022 | | 372 | 1532 |
| 12 | Taylor Cook | Lesterville | 2008-2011 | | 266 | 1484 |
| 13 | Maya Witherspoon | Lafayette (Wildwood) | 2021-2024 | | 403 | 1467 |
| 14 | Angel Johnson | Clarkton | 2021-2024 | | 433 | 1454 |
| 15 | Autumn Craft | Verona | 1995-1998 | | 310 | 1401 |
| 16 | Christi Myers | Raytown South | 1995-1998 | | 274 | 1399 |
| 17 | Kaitlyn Belk | Bunker | 2019-2022 | | 323 | 1374 |
| 18 | Marianne Beal | Lee's Summit North | 2006-2009 | | 303 | 1330 |
| 18 | Marianne Elizab Beal | Lee's Summit North | 2006-2009 | | 303 | 1330 |
| 20 | Jamie Roszell | East Newton | 1995-1998 | | 251 | 1303 |
| 21 | Kaitlyn M. Creek | Stockton | 2016-2019 | | 256 | 1265 |
| 22 | Baylee Russ | Midway | 2018-2022 | | 333 | 1243 |
| 23 | Morgan Beal | Lee's Summit North | 2009-2012 | | 319 | 1239 |
| 23 | Morgan N. Beal | Lee's Summit North | 2009-2012 | | 319 | 1239 |
| 25 | Salma Lewis | Carl Junction | 2017-2020 | Career kills | 327 | 1227 |
| 26 | Lauren Standlee | Thomas Jefferson Independent | 1997-2000 | | 263 | 1208 |
| 27 | Avery McVicker | Cameron | 2018-2021 | | 293 | 1198 |
| 27 | Rilyn Sherwood | East Buchanan | 2021-2024 | | 373 | 1198 |
| 29 | Maya Watkins | East Buchanan | 2019-2022 | | 308 | 1197 |
| 30 | Jaycee Theo Fixsen | Nixa | 2018-2021 | | 369 | 1191 |
| 31 | Kara Schilli | Valle Catholic | 2001-2004 | | 271 | 1190 |
| 31 | Cameron Layne Dake | Mt. Vernon | 2012-2015 | | 284 | 1190 |
| 33 | Tera Reberry | Pleasant Hill | 2017-2020 | | 247 | 1180 |
| 34 | Kylie Scott | Carl Junction | 2020-2023 | | 325 | 1173 |
| 35 | Aubrey Cheffey | Nixa | 2012-2015 | | 269 | 1168 |
| 36 | Marissa Hundelt | Orchard Farm | 2006-2009 | | 230 | 1165 |
| 37 | Catherine Elizabeth Woolf | North Point | 2020-2023 | | 359 | 1161 |
| 38 | Anna Harrold | Lawson | 2019-2022 | | 335 | 1138 |
| 38 | Anna Harrold | Lawson | 2019-2022 | | 335 | 1138 |
| 40 | Rebekah Wedick | Willow Springs | 1996-1999 | | 253 | 1123 |
| 41 | Mikayla Bonnell | Licking | 2015-2017 | | 231 | 1108 |
| 42 | Kirstyn Michele Loyd | Jefferson (Festus) | 2019-2022 | | 349 | 1084 |
| 43 | Sidney Hawkins | Lesterville | 2021-2024 | | 400 | 1081 |
| 44 | Megan Howard | Bolivar | 2021-2024 | | 395 | 1079 |
| 45 | Amelia Flynn | Timberland | 2014-2017 | | 250 | 1045 |
| 46 | Emma Allyn Breier | Jefferson (Festus) | 2019-2022 | | 345 | 1036 |
| 47 | Cora Roweton | Bolivar | 2019-2022 | | 372 | 1032 |
| 48 | Haylie Marie Schnake | Miller | 2019-2022 | | 368 | 1031 |
| 49 | Lisa Downey | Lafayette (Wildwood) | 1998-2000 | | 295 | 1030 |
| 50 | Arianna Nower | West Platte | 2021-2024 | | 338 | 1005 |
| 51 | Ryenne Olivia Gepford | Butler | 2017-2020 | | 281 | 1000 |
| 52 | Regan Michele Peltier | Nixa | 2008-2011 | | 313 | 980 |
| 53 | Dailynn VanDeren | Bolivar | 2019-2022 | | 370 | 977 |
| 54 | Lily Johnson | Lafayette (Wildwood) | 2010-2013 | | 264 | 974 |
| 55 | Katie Panhorst | St. Charles | 1993-1995 | | 158 | 957 |
| 56 | Emberlynn M Kingsley | Miller | 2019-2022 | | 329 | 936 |
| 57 | Cameryn Cassity | Mt. Vernon | 2018-2021 | | 307 | 918 |
| 58 | Alyxandra Marie Gepford | Butler | 2010-2013 | | 282 | 901 |
| 59 | Ava Kay Roth | Jefferson (Festus) | 2019-2022 | | 349 | 889 |
| 60 | Makenna Irvin | Midway | 2014-2017 | | 273 | 877 |
| 61 | Holly Caylor | East Buchanan | 2020-2023 | | 347 | 832 |
| 61 | Paige Hurley | Hollister | 2021-2024 | | 295 | 832 |
| 63 | Kelsey Stewart | Mt. Vernon | 2002-2005 | 2 out 3 sets | 277 | 774 |
| 64 | Julie Williams | St. Charles | 1992-1994 | | 164 | 765 |
| 65 | Ellie Johnston | Mt. Vernon | 2017-2020 | | 317 | 753 |
| 66 | Hannah Medlock | Licking | 2020-2022 | | 232 | 715 |
| 67 | Morgan Hull | Mt. Vernon | 2013-2016 | | 293 | 701 |
| 68 | | Bayless | 2022-2024 | | 241 | 684 |
| 69 | Danielle E Goodman | Mt. Vernon | 2009-2011 | | 214 | 646 |
| 70 | Tamiaya S Henderson | Mt. Vernon | 2009-2012 | | 207 | 631 |
| 71 | Rachel Carr | Bolivar | 2018-2021 | | 322 | 584 |
| 72 | Hilah Fish | Jefferson (Festus) | 2013-2016 | 3 years Varsity | 181 | 580 |
| 73 | Abigail Sullins | Licking | 2019-2022 | | 265 | 578 |
| 74 | Abagail Moncrief | Licking | 2016-2019 | | 279 | 478 |
| 75 | Bailie Osborne | Licking | 2011-2014 | | 220 | 477 |
| 76 | Kamryn Barnes | Licking | 2017-2020 | | 262 | 467 |
| 77 | Abigail Cole | Licking | 2016-2019 | | 291 | 420 |
| 78 | Emily Smith | Licking | 2010-2013 | | 143 | 328 |