| Rank | Student | School | Years | | G | 2B |
| 1 | Blake DeWitt | Sikeston | 2001-2004 | | 107 | 50 |
| 2 | Rylan Michel | Nixa | 2020-2024 | | 130 | 48 |
| 3 | Ben Turner | Westminster Christian Academy | 2005-2008 | | 109 | 47 |
| 3 | Nathan Geile | Valle Catholic | 2007-2010 | | 116 | 47 |
| 5 | Jeff Melton | Herculaneum | 200-2003 | | 106 | 45 |
| 6 | Ronnie Calvird | Central (Park Hills) | 2004-2007 | | 96 | 44 |
| 6 | Aaron Basler | Valle Catholic | 2007-2010 | | 116 | 44 |
| 6 | Jeremy Eierman | Warsaw | 2011-2014 | | 90 | 44 |
| 9 | Adam Mason | Christian Brothers College | 1997-2000 | | 115 | 43 |
| 10 | Greg Rodgers | Francis Howell | 2000-2003 | | 113 | 42 |
| 11 | Matt Shevchuk | Mansfield | 1998-2001 | | 82 | 40 |
| 11 | Ryan Smith | Hermitage | 2005-2008 | | 83 | 40 |
| 11 | Grant Hollister | Blue Springs South | 2020-2023 | | 136 | 40 |
| 14 | Tyson Shields | Nixa | 1998-2000 | | 83 | 39 |