| Rank | Student | School | Years | | G | AB |
| 1 | Tytus A Cissell | Francis Howell | 2020-2023 | | 158 | 457 |
| 2 | Chris Cornelius | Vianney | 2013-2016 | | 138 | 407 |
| 3 | Blake DeWitt | Sikeston | 2001-2004 | | 107 | 379 |
| 4 | Greg Rodgers | Francis Howell | 2000-2003 | | 113 | 378 |
| 5 | Chase Morris | Southern Boone | 2020-2023 | | 133 | 377 |
| 6 | Connor S Basler | Valle Catholic | 2012-2015 | | 116 | 373 |
| 7 | Nathan Gelle | Valle Catholic | 2007-2010 | | 116 | 370 |
| 7 | Austin Evans | Southern Boone | 2020-2023 | | 112 | 370 |
| 9 | Brock Allen Miles | Capital City | 2020-2023 | | 117 | 367 |
| 10 | Matt Brown | Vianney | 2010-2013 | | 124 | 366 |
| 11 | Tate Matheny | Westminster Christian Academy | 2009-2012 | | 111 | 364 |
| 12 | Adam Mason | Christian Brothers College | 1997-2000 | | 115 | 360 |
| 13 | Ben Turner | Westminster Christian Academy | 2005-2008 | | 109 | 352 |
| 14 | Jacob Turner | Westminster Christian Academy | 2006-2009 | | 115 | 351 |
| 15 | Luke Turner | Westminster Christian Academy | 2009-2012 | | 116 | 345 |
| 16 | Robert Mitchell | Herculaneum | 1998-2001 | | 105 | 339 |
| 17 | James Berry | Lilbourn | 1974-1977 | | 113 | 335 |
| 17 | Jeff Melton | Herculaneum | 2000-2003 | | 106 | 335 |
| 17 | Chase Krogman | Liberty (Wentzville) | 2016-2019 | | 106 | 335 |
| 20 | Jack Klages | Vianney | 2010-2013 | | 102 | 326 |
| 21 | Luke Mann | Vianney | 2015-2018 | | 147 | 306 |