| Rank | Student | Grade | School | Year | | G | Ast |
| 1 | Jake McCutcheon | Sr | Francis Howell | 2021 | | 42 | 89 |
| 2 | Jake McCutcheon | Jr | Francis Howell | 2020 | | 32 | 86 |
| 2 | Tytus Cissell | Jr | Francis Howell | 2022 | | 42 | 86 |
| 4 | Grant Merryman | Sr | Willard | 2020 | | 37 | 84 |
| 5 | Ryan Haverstick | Jr | Westminster Christian Academy | 2006 | | 28 | 82 |
| 6 | Jackson Lewis | Jr | Plattsburg | 2021 | | 38 | 80 |
| 7 | Tyler Ehrlich | Sr | Francis Howell | 2016 | | 34 | 78 |
| 8 | Kayden Carter | Sr | Plattsburg | 2021 | | 37 | 75 |
| 9 | Bret Gallion | Jr | Parkview | 2005 | | 27 | 73 |
| 9 | | Jr | Francis Howell | 2009 | | 31 | 73 |
| 9 | Zac Perkins | Jr | Francis Howell | 2010 | | 31 | 73 |
| 9 | Brett Peel | Sr | Francis Howell | 2011 | | 35 | 73 |
| 13 | Tytus A Cissell | Sr | Francis Howell | 2023 | | 42 | 72 |
| 14 | Tony Sargent | So | Francis Howell | 1999 | | 31 | 71 |
| 15 | Michael Ferrera | Sr | Westminster Christian Academy | 2010 | | 31 | 68 |
| 15 | Brett Graves | Sr | Francis Howell | 2011 | | 31 | 68 |
| 17 | Joe Boyer | Sr | Hillsboro | 1999 | | 27 | 67 |
| 18 | Dack Sandborn | Jr | Webb City | 2015 | | 28 | 65 |
| 19 | Dack Sandborn | Sr | Webb City | 2016 | | 32 | 64 |
| 20 | Jake Rains | Sr | Liberty | 2003 | | 31 | 63 |
| 21 | Jeff Reed | Jr | Northwest (Cedar Hill) | 2014 | | 27 | 62 |
| 22 | Wes Melber | Sr | Hillsboro | 1995 | | 18 | 61 |
| 22 | Joe Boyer | So | Hillsboro | 1997 | | 27 | 61 |
| 22 | Mark Parker | Sr | Hillsboro | 2000 | | 28 | 61 |
| 22 | Bob Hankins | Sr | Hillsboro | 2001 | | 27 | 61 |
| 26 | Aden Johnson | Sr | Francis Howell | 2022 | | 42 | 52 |
| 27 | Brady Wilson | Jr | Francis Howell | 2021 | | 42 | 49 |
| 27 | Henley Allen Parker | Sr | Jackson | 2022 | | 41 | 49 |
| 29 | Jackson Ramsey Wyatt | Sr | Jackson | 2022 | | 41 | 38 |
| 30 | | Sr | Francis Howell | 2022 | | 42 | 35 |
| 31 | Caleb Miller | Jr | Francis Howell | 2021 | | 42 | 34 |
| 31 | Quinton Alexander Borders | Sr | Jackson | 2022 | | 41 | 34 |