| Rank | Student | Grade | School | Year | | G | SO |
| 1 | Tyler Abma | So | Miller | 2007 | | 12 | 177 |
| 2 | Clifford Kiely | Sr | Leeton | 2006 | | 20 | 172 |
| 3 | Gaven Mooney | Sr | Lone Jack | 2020 | | 16 | 166 |
| 4 | Chris Gerleman | Sr | Marion C. Early | 2002 | | 13 | 164 |
| 5 | Gavin Claud | Sr | Carrollton | 2020 | | 13 | 157 |
| 6 | Robbie Ewing | Jr | Stockton | 2010 | | 26 | 155 |
| 7 | Joe Kassanavoid | Sr | Lawson | 2008 | | 13 | 154 |
| 8 | Chris Mackey | Sr | Springfield Catholic | 2004 | | 13 | 150 |
| 9 | Matt Frevert | Sr | Hallsville | 2005 | | 14 | 149 |
| 10 | Mathias Miller | So | Conway | 2000 | | 17 | 145 |
| 11 | Tristan Engle | Sr | Concordia | 2003 | | 16 | 143 |
| 11 | Wyatt Baker Sparks | Sr | Aurora | 2017 | | 15 | 143 |
| 13 | Tyler Burgess | Jr | Webb City | 2010 | | 14 | 142 |
| 13 | Colten Selvey | Sr | Liberal | 2012 | | 12 | 142 |
| 15 | Levi Matthew McKinnie | Jr | Chaffee | 2022 | | 16 | 122 |
| 16 | Gage Pearson | Jr | Putnam County | 2020 | 56.2 IP | 14 | 118 |
| 16 | Lukas Barnes | Sr | Cooter | 2022 | 63.0 | 32 | 118 |
| 18 | Kolton Clark | Sr | Belle | 2013 | | 13 | 112 |
| 18 | Tristan Hunter | Jr | Forsyth | 2022 | | 12 | 112 |
| 18 | Mason Morris | Jr | Putnam County | 2023 | | 14 | 112 |
| 21 | Haden Terrill | So | Wellington-Napoleon | 2022 | | 24 | 110 |
| 22 | Samuel Peyton Hodges | Jr | East Prairie | 2021 | | 12 | 109 |
| 23 | Gage Pearson | Sr | Putnam County | 2021 | 51.1 IP | 14 | 107 |
| 23 | Samuel Peyton Hodges | Sr | East Prairie | 2022 | | 13 | 107 |
| 23 | Mason Schirmer | Jr | Festus | 2023 | | 11 | 107 |
| 26 | Triston Joseph Bruegman | Sr | Marion C. Early | 2022 | | 14 | 106 |
| 27 | Caden Reece Bogenpohl | Sr | Jackson | 2022 | | 15 | 105 |
| 27 | Landon Matthew Krohn | Jr | Princeton | 2022 | | 22 | 105 |
| 27 | Landon Matthew Krohn | Jr | Princeton | 2022 | | 11 | 105 |
| 30 | Sean Jarod Phillips | Fr | Elsberry | 2020 | | 11 | 104 |
| 31 | Casen Murphy | So | Central (Park Hills) | 2022 | 56.2 Innings | 10 | 103 |
| 31 | Clayton Shockley | Sr | Belle | 2023 | | 10 | 103 |
| 33 | Tristan Hunter | So | Forsyth | 2021 | | 10 | 98 |
| 33 | Tristan Hunter | Sr | Forsyth | 2023 | | 9 | 98 |
| 33 | Dalton Hartman | Sr | Summersville | 2023 | | 20 | 98 |
| 36 | Levi Matthew McKinnie | Sr | Chaffee | 2023 | 61 innings | 15 | 97 |
| 37 | Garyn Hall | Sr | Houston | 2022 | | 25 | 94 |
| 38 | John paul Robert Sauer, V | Jr | Jackson | 2022 | | 13 | 93 |
| 38 | Levi Matthew McKinnie | So | Chaffee | 2023 | 58.1 innings | 14 | 93 |
| 40 | Tyler Norrick | Sr | Festus | 2002 | 42 innings | 9 | 87 |
| 41 | Philip (PJ) Alexander Schmidt, Jr. | Sr | South Shelby | 2022 | | 12 | 86 |
| 42 | Tristan Hunter | Fr | Forsyth | 2020 | | 15 | 83 |
| 43 | Alec Brown | Sr | Chaffee | 2020 | 57.1 innings | 13 | 80 |
| 43 | Brysen Nepute | Sr | Francis Howell | 2022 | | 12 | 80 |
| 45 | Drew Horrell | Sr | Festus | 2004 | 50.2 innings | 10 | 73 |
| 45 | Mason Schirmer | So | Festus | 2022 | in 51 innings | 35 | 73 |