| Rank | Student | Grade | School | Year | | IP | H | BF |
| 1 | Ben Neuner | Jr | Linn | 2004 | | 81.1 | 86 | 363 |
| 2 | Toby Hartsell | Sr | Walnut Grove | 1989 | | 68.1 | -1 | 358 |
| 3 | Robbe Ewing | Jr | Stockton | 2010 | | 82 | -1 | 346 |
| 4 | Jay Marshall | Sr | John F. Kennedy High School | 2001 | | 87.2 | 60 | 339 |
| 5 | Joe Kassanavoid | Sr | Lawson | 2008 | | 77.2 | -1 | 331 |
| 6 | James Brock Steggall | Sr | Plattsburg | 2021 | | 82.1 | 43 | 329 |
| 7 | Jay Marshall | Jr | John F. Kennedy High School | 2000 | | 84.1 | 56 | 326 |
| 8 | Mark Harvey | Sr | Westran | 1997 | | 94 | 42 | 322 |
| 9 | Josh McMillen | Jr | Sullivan | 2005 | | 68.1 | -1 | 321 |
| 9 | Brysen Nepute | Jr | Francis Howell | 2021 | | 63 | 73 | 321 |
| 11 | Lucas Cashman | Sr | Tipton | 2024 | | 79 | 45 | 319 |
| 12 | Joe Hope | So | Parkway North | 2012 | | 72 | 68 | 316 |
| 13 | Lucas Cashman | Jr | Tipton | 2023 | | 74 | 57 | 312 |
| 14 | Brandon Bishop | Sr | Wright City | 2005 | | 6 | -1 | 310 |
| 15 | Blaine Abbott | Jr | New Haven | 2007 | | 63.1 | 63 | 309 |
| 16 | Zack Mesey | So | Sullivan | 2007 | | 69.2 | 56 | 305 |
| 16 | Cody Burkhardt | Jr | Hermitage | 2008 | | 64.2 | 38 | 305 |