| Rank | IP | Student | Grade | School | Year | |
| 1 | 42.1 | Charlie Lowell | | Winfield | 2008 | 3/24 - 5/5 |
| 2 | 40 | Mason Morris | Jr | Putnam County | 2023 | |
| 3 | 33.2 | Tyler Burgess | | Webb City | 2011 | |
| 4 | 33 | Jacob Turner | | Westminster Christian Academy | 2008 | |
| 5 | 32 | Trevor Pipes | So | La Plata | 2016 | |
| 6 | 29 | John paul Robert Sauer, V | Jr | Jackson | 2022 | |
| 7 | 27 | Robbe Ewing | | Stockton | 2010 | |
| 8 | 26 | Gerrion Grim | | Ft. Zumwalt South | 2011 | |
| 9 | 25 | Gary Moppin | | Mid-Buchanan | 2004 | 4 Games |
| 10 | 24 | Jacob Turner | | Westminster Christian Academy | 2007 | |
| 10 | 24 | Colin Thomas Kelley | Jr | Nixa | 2023 | |
| 12 | 23.2 | Tom McVey | | St. Mary's (St. Louis) | 2005 | |
| 13 | 22.1 | Mark Reeder | Sr | Parkway North | 2003 | 4 games |
| 14 | 22 | Joe McLaughlin | | Lexington | 2007 | |
| 14 | 22 | Mason Sander | | Jackson | 2010 | 4 Games |
| 16 | 21 | Jacob Turner | | Westminster Christian Academy | 2009 | |