| Rank | Student | Grade | School | Year | | SB | G | PerG |
| 1 | David Miller | Sr | Belle | 1983 | | 51 | 16 | 3.188 |
| 2 | Kimo Concepcion | Jr | Stoutland | 1999 | | 47 | 17 | 2.765 |
| 3 | Kimo Concepcion | So | Stoutland | 1998 | | 44 | 16 | 2.750 |
| 4 | Cody Burkhardt | Sr | Hermitage | 2009 | | 56 | 21 | 2.667 |
| 5 | Jayden Hasam | Fr | University Academy Charter | 2020 | | 49 | 19 | 2.579 |
| 6 | Jared Alverson | Jr | Exeter | 2017 | | 58 | 23 | 2.522 |
| 7 | Jayden Hasam | So | University Academy Charter | 2021 | | 64 | 27 | 2.370 |
| 8 | James Gowin | Sr | Hermitage | 2008 | | 55 | 24 | 2.292 |
| 9 | Garrett Mork | So | Bismarck | 2021 | | 50 | 22 | 2.273 |
| 9 | Garrett Mork | So | Bismarck | 2021 | | 50 | 22 | 2.273 |
| 11 | Demetrius Brooks | Sr | McCluer South-Berkeley | 2007 | | 37 | 17 | 2.176 |
| 12 | Lucas Robert Efken | Sr | Bayless | 2022 | | 50 | 23 | 2.174 |
| 13 | Garrett Mork | Jr | Bismarck | 2022 | | 42 | 20 | 2.100 |
| 14 | Justin Coliny | Sr | Wright City | 2002 | | 33 | 16 | 2.063 |
| 15 | Garrett Mork | Sr | Bismarck | 2023 | | 47 | 23 | 2.043 |
| 16 | Aaron Garner | Jr | Pierce City | 2018 | | 48 | 24 | 2.000 |
| 16 | Danny Maier | Sr | New Franklin | 2004 | | 42 | 21 | 2.000 |
| 16 | Colin Gowin | So | Hermitage | 2010 | | 42 | 21 | 2.000 |
| 19 | Garyn Hall | Sr | Houston | 2022 | | 51 | 26 | 1.962 |
| 20 | Garyn Hall | Sr | Houston | 2022 | | 49 | 25 | 1.960 |
| 21 | Nick Moore | Sr | Wright City | 2022 | | 45 | 23 | 1.957 |
| 21 | Nick Moore | Sr | Wright City | 2022 | | 45 | 23 | 1.957 |
| 23 | Shane Lower | Fr | New Bloomfield | 2003 | | 39 | 20 | 1.950 |
| 24 | | Jr | Houston | 2021 | | 40 | 23 | 1.739 |
| 24 | Garyn Hall | Jr | Houston | 2021 | | 40 | 23 | 1.739 |
| 26 | Garyn Hall | So | Houston | 2020 | | 33 | 20 | 1.650 |
| 27 | Kaden Matthew Kinsler | So | Elsberry | 2020 | | 37 | 25 | 1.480 |
| 28 | Zachary Kent Craig | Sr | Summersville | 2021 | | 20 | 14 | 1.429 |
| 29 | Aiden S Heberlie | Jr | Valle Catholic | 2020 | | 47 | 33 | 1.424 |
| 30 | Zeke Jones | Sr | Summersville | 2023 | | 28 | 20 | 1.400 |
| 31 | Carson Nicholas Schmidt | Sr | Benton | 2024 | | 50 | 36 | 1.389 |
| 32 | Kaden Matthew Kinsler | Jr | Elsberry | 2021 | | 35 | 30 | 1.167 |
| 33 | Ryker Zimmerman | Jr | Southern Boone | 2022 | | 38 | 35 | 1.086 |
| 34 | Brady Nolen | Jr | Festus | 2023 | | 27 | 25 | 1.080 |
| 35 | Tyler Lutjen | Sr | Clinton | 2020 | | 28 | 26 | 1.077 |
| 36 | Kasen Gaston | Jr | Summersville | 2023 | | 21 | 20 | 1.050 |
| 37 | Grant Douglas Dotson | Sr | Jackson | 2022 | | 41 | 41 | 1.000 |
| 38 | | Jr | Clinton | 2016 | | 21 | 22 | .955 |
| 38 | Trey Miller | Jr | Clinton | 2016 | | 21 | 22 | .955 |
| 40 | Zeke Jones | Jr | Summersville | 2022 | | 18 | 19 | .947 |
| 41 | | Sr | Southern Boone | 2023 | | 35 | 37 | .946 |
| 42 | Crockett Parham | Sr | Summersville | 2018 | | 16 | 17 | .941 |
| 43 | | Sr | Houston | 2022 | | 24 | 26 | .923 |
| 43 | Danny Lee Venable | Sr | Houston | 2022 | | 24 | 26 | .923 |
| 45 | Gavin Jansen | Sr | Kelly | 2021 | | 23 | 25 | .920 |
| 46 | Caden Reece Bogenpohl | Sr | Jackson | 2022 | | 37 | 41 | .902 |
| 47 | Aiden Kelly | Jr | Houston | 2022 | | 22 | 25 | .880 |
| 48 | Gavin Jansen | Sr | Kelly | 2020 | | 23 | 28 | .821 |
| 49 | Connor Earleywine | Jr | Jefferson City | 2020 | | 29 | 37 | .784 |
| 50 | Quinton Alexander Borders | Sr | Jackson | 2022 | | 31 | 41 | .756 |
| 50 | Cooper Phillip Rhodes | So | Jackson | 2022 | | 31 | 41 | .756 |
| 52 | Clayton Shockley | Sr | Belle | 2023 | | 15 | 21 | .714 |
| 53 | Jackson Ramsey Wyatt | Sr | Jackson | 2022 | | 27 | 41 | .659 |
| 54 | Henley Allen Parker | Sr | Jackson | 2022 | | 25 | 41 | .610 |
| 55 | Landon James Watkins | Sr | Jackson | 2022 | | 23 | 41 | .561 |