| Rank | Student | Grade | School | Year | | G | Total |
| 1 | Kyle White | Jr | Christian Brothers College | 1976 | | 20 | 42 |
| 1 | Kayden Carter | Sr | Plattsburg | 2021 | | 37 | 42 |
| 3 | Cameron Chick | Sr | Hickman | 2017 | | 38 | 36 |
| 4 | Glen Verslues | So | Helias Catholic | 1987 | | 27 | 35 |
| 5 | James Brock Steggall | Sr | Plattsburg | 2021 | | 38 | 34 |
| 6 | John Cassmeyer | Sr | Helias Catholic | 1980 | | 26 | 32 |
| 6 | James Abel | Sr | West County | 2005 | | 22 | 32 |
| 6 | Will Young | Fr | Plato | 2007 | | 23 | 32 |
| 6 | Jack Welch | Sr | Bernie | 2010 | | 26 | 32 |
| 10 | Leon Davenport | Jr | Grandview | 1999 | | 20 | 31 |
| 10 | Shane Noel | Sr | Webb City | 2020 | | 32 | 31 |
| 10 | Thomas A Andert | Sr | Southern Boone | 2021 | | 36 | 31 |
| 13 | Sammy Taylor | Sr | Lilbourn | 1976 | | 24 | 30 |
| 13 | Ryan Hirsch | Sr | Parkway West | 1994 | | 25 | 30 |
| 13 | Mark Fisher | Sr | Central (Cape Girardeau) | 2000 | | 29 | 30 |
| 13 | Aaron Henry | Sr | Thayer | 2005 | | 26 | 30 |
| 17 | Ryan Perkins | Sr | Francis Howell | 2016 | | 40 | 29 |
| 17 | Gage Michael Singer | Sr | Aurora | 2018 | | 27 | 29 |
| 19 | Jackson Lewis | Jr | Plattsburg | 2021 | | 38 | 28 |
| 20 | Sam Maddox | Sr | Francis Howell | 2020 | | 38 | 27 |
| 20 | Leo Humbert | Fr | Francis Howell | 2021 | | 42 | 27 |
| 22 | Cameron Michael Witt | Jr | Monett | 2014 | | 28 | 26 |
| 22 | Collin Murray | Sr | Iberia | 2017 | | 22 | 26 |
| 22 | David Clay Kemp | Jr | Hollister | 2020 | | 32 | 26 |
| 25 | Nicholas Drew Roberts | Sr | Monett | 2012 | | 26 | 24 |
| 25 | Mathew Miller | Sr | Aurora | 2017 | | 32 | 24 |
| 27 | Grant Zeigenbein | Jr | Stoutland | 2018 | | 23 | 23 |
| 27 | Case Sanderson | Jr | Nevada | 2021 | | 24 | 23 |
| 29 | Jared Alverson | Jr | Exeter | 2017 | | 23 | 22 |
| 29 | Zach Craig | Jr | Summersville | 2020 | | 22 | 22 |
| 31 | James Brock Steggall | Jr | Plattsburg | 2020 | | 22 | 21 |
| 32 | Laydon Fields | Fr | Green City | 2018 | | 16 | 19 |
| 32 | Brett Norfleet | Jr | Francis Howell | 2021 | | 42 | 19 |
| 32 | Brysen Nepute | Jr | Francis Howell | 2021 | | 42 | 19 |
| 35 | Jaden Thacker | Sr | Winona | 2020 | | 17 | 14 |