| Rank | Student | Grade | School | Year | | RBI | G | PerG |
| 1 | Michael Troth | Sr | Southern Boone | 2003 | | 61 | 23 | 2.652 |
| 2 | Chris Julo | Sr | Grandview | 1999 | | 49 | 19 | 2.579 |
| 3 | Ryan Thomas | Sr | Sacred Heart | 2002 | | 51 | 21 | 2.429 |
| 4 | Matt Mabe | Sr | Steelville | 1997 | | 48 | 20 | 2.400 |
| 5 | Jake Whitesides | Jr | Hickman | 1999 | | 57 | 24 | 2.375 |
| 6 | Jaric Reid | Jr | Sacred Heart | 2006 | | 56 | 24 | 2.333 |
| 7 | Joe Lincoln | Sr | Tipton | 2007 | | 51 | 22 | 2.318 |
| 8 | Jake Blackwood | Jr | Platte County | 2003 | | 54 | 24 | 2.250 |
| 8 | Calab Kaufman | Fr | Weaubleau | 2010 | | 54 | 24 | 2.250 |
| 10 | Blake DeWitt | Jr | Sikeston | 2003 | | 56 | 25 | 2.240 |
| 11 | Braden Spawr | Jr | Valley Park | 2017 | | 63 | 30 | 2.100 |
| 12 | Chase Spoonemore | Jr | Savannah | 2018 | | 49 | 27 | 1.815 |
| 13 | Treghan Parker | Sr | Webb City | 2020 | Spring of 2021 | 56 | 32 | 1.750 |
| 14 | Kelby Steven Thomas | Jr | Princeton | 2022 | | 36 | 22 | 1.636 |
| 14 | Kelby Steven Thomas | Jr | Princeton | 2022 | | 36 | 22 | 1.636 |
| 16 | Tristan Duncan | Jr | Summersville | 2021 | | 22 | 14 | 1.571 |
| 17 | Luke Mann | Sr | Vianney | 2018 | | 61 | 39 | 1.564 |
| 18 | Tanner Sears | Sr | Lafayette County | 2018 | | 33 | 22 | 1.500 |
| 19 | Chase Edwards | Sr | Lafayette County | 2017 | | 31 | 24 | 1.292 |
| 20 | Brett Norfleet | Jr | Francis Howell | 2021 | | 54 | 42 | 1.286 |
| 21 | Baden Luke Hackworth | Sr | Jackson | 2022 | | 52 | 41 | 1.268 |
| 22 | Mason Gash | So | Lafayette County | 2017 | | 30 | 24 | 1.250 |
| 23 | Mason Gash | Jr | Lafayette County | 2018 | | 28 | 23 | 1.217 |
| 24 | Ethan Puckett | Sr | Alton | 2023 | | 30 | 26 | 1.154 |
| 25 | Caden Reece Bogenpohl | Sr | Jackson | 2022 | | 45 | 41 | 1.098 |
| 25 | Quinton Alexander Borders | Sr | Jackson | 2022 | | 45 | 41 | 1.098 |
| 27 | Brett Norfleet | Sr | Francis Howell | 2022 | | 44 | 42 | 1.048 |
| 28 | Kade Clary | Fr | Alton | 2023 | | 26 | 26 | 1.000 |