| Rank | Student | Grade | School | Year | | G | RBI |
| 1 | Braden Spawr | Jr | Valley Park | 2017 | | 30 | 63 |
| 2 | Michael Troth | Sr | Southern Boone | 2003 | | 23 | 61 |
| 2 | Luke Mann | Sr | Vianney | 2018 | | 39 | 61 |
| 4 | Travis Johnson | Sr | Odessa | 1998 | | 29 | 60 |
| 5 | Case Munson | Sr | Francis Howell | 2011 | | 33 | 59 |
| 6 | Jake Whitesides | Jr | Hickman | 1999 | | 24 | 57 |
| 6 | Jake Owens | Sr | Bernie | 2010 | | 26 | 57 |
| 8 | Ryan Hetzer | Jr | Whitfield | 1994 | | 26 | 56 |
| 8 | Blake DeWitt | Jr | Sikeston | 2003 | | 25 | 56 |
| 8 | Anthony Martin | Sr | Thayer | 2005 | | 27 | 56 |
| 8 | Jaric Reid | Jr | Sacred Heart | 2006 | | 24 | 56 |
| 8 | Treghan Parker | Sr | Webb City | 2020 | Spring of 2021 | 32 | 56 |
| 8 | Treghan Parker | Sr | Webb City | 2020 | | 32 | 56 |
| 14 | Corey Limpert | Sr | Herculaneum | 1999 | | 27 | 55 |
| 14 | Gus Durst | Sr | Houston | 2007 | | 25 | 55 |
| 16 | Brett Norfleet | Jr | Francis Howell | 2021 | | 42 | 54 |
| 17 | Baden Luke Hackworth | Sr | Jackson | 2022 | | 41 | 52 |
| 18 | Chase Spoonemore | Jr | Savannah | 2018 | | 27 | 49 |
| 19 | Caden Reece Bogenpohl | Sr | Jackson | 2022 | | 41 | 45 |
| 19 | Quinton Alexander Borders | Sr | Jackson | 2022 | | 41 | 45 |
| 21 | Brett Norfleet | Sr | Francis Howell | 2022 | | 42 | 44 |
| 22 | Kelby Steven Thomas | Jr | Princeton | 2022 | | 22 | 36 |
| 23 | Tanner Sears | Sr | Lafayette County | 2018 | | 22 | 33 |
| 24 | Chase Edwards | Sr | Lafayette County | 2017 | | 24 | 31 |
| 25 | Mason Gash | So | Lafayette County | 2017 | | 24 | 30 |
| 25 | Ethan Puckett | Sr | Alton | 2023 | | 26 | 30 |
| 27 | Mason Gash | Jr | Lafayette County | 2018 | | 23 | 28 |
| 28 | Kade Clary | Fr | Alton | 2023 | | 26 | 26 |
| 29 | Tristan Duncan | Jr | Summersville | 2021 | | 14 | 22 |