| Rank | Student | Grade | School | Year | | G | 2B |
| 1 | Justin Jackson | Sr | Hickman | 2005 | | 30 | 20 |
| 2 | Shawn Hampy | Jr | Northwest (Hughesville) | 2001 | | 26 | 19 |
| 2 | Truman Marek | Jr | Bishop LeBlond | 2002 | | 21 | 19 |
| 2 | Eli Dilday | Sr | Francis Howell | 2013 | | 40 | 19 |
| 2 | | Sr | Westminster Christian Academy | 2017 | | 32 | 19 |
| 6 | Don Lambert | Sr | Westminster Christian Academy | 2007 | | 28 | 18 |
| 6 | Michael Bozarth | Sr | Parkway North | 2012 | | 34 | 18 |
| 6 | Grant Wood | Sr | Jefferson City | 2017 | | 33 | 18 |
| 9 | Jonathan Maestas | Sr | Wright City | 2006 | | 23 | 17 |
| 9 | Joe Lincoln | Sr | Tipton | 2007 | | 22 | 17 |
| 9 | Jordan Hammerman | Jr | Ladue Horton Watkins | 2008 | | 29 | 17 |
| 9 | Derek Rallo | Sr | Christian Brothers College | 2010 | | 33 | 17 |
| 9 | Jeremy Eierman | Jr | Warsaw | 2013 | | 24 | 17 |
| 9 | Chris Cornelius | So | Vianney | 2014 | | 38 | 17 |
| 9 | Nick Allgeyer | Sr | Vianney | 2014 | | 38 | 17 |
| 9 | Calvin Blake Heidenwith | Sr | Putnam County | 2016 | | 19 | 17 |
| 9 | Bryce Phelps | Jr | Kelly | 2020 | | 28 | 17 |
| 18 | Jeff Melton | So | Herculaneum | 2001 | | 29 | 16 |
| 18 | Ryan Jackson | Sr | Ft. Zumwalt West | 2005 | | 29 | 16 |
| 18 | John Lyons | Jr | Herculaneum | 2005 | | 27 | 16 |
| 18 | Justin Juergensmeyer | Sr | Troy Buchanan | 2005 | | 29 | 16 |
| 18 | Luke Schlecte | Jr | Windsor (Imperial) | 2006 | | 26 | 16 |
| 18 | Jaric Reid | Jr | Sacred Heart | 2006 | | 24 | 16 |
| 18 | Chance Sossamon | Sr | Webb City | 2007 | | 23 | 16 |
| 18 | Gus Durst | Sr | Houston | 2007 | | 25 | 16 |
| 18 | Jacob Childers | Sr | Conway | 2010 | | 30 | 16 |
| 18 | Dylan Rowe | Sr | Christian Brothers College | 2010 | | 33 | 16 |
| 18 | Ryan Light | Sr | Ft. Zumwalt South | 2011 | | 27 | 16 |
| 18 | Jake McCutcheon | Sr | Francis Howell | 2021 | | 41 | 16 |
| 18 | Baden Luke Hackworth | Sr | Jackson | 2022 | | 41 | 16 |
| 31 | Adam Whitehead | Sr | Festus | 2002 | | 26 | 15 |
| 31 | Jace Reynolds | Jr | Southern Boone | 2022 | | 35 | 15 |
| 33 | Stone Krogman | Jr | Liberty (Wentzville) | 2016 | | 27 | 14 |
| 33 | Tanner Sears | Jr | Lafayette County | 2017 | | 23 | 14 |
| 33 | Case Sanderson | Jr | Nevada | 2021 | | 24 | 14 |
| 36 | Kyle Morris | Sr | Festus | 2006 | | 27 | 13 |
| 36 | Braeden Hinton | Sr | Nevada | 2017 | | 24 | 13 |
| 36 | Ty Powers | Sr | Kelly | 2021 | | 24 | 13 |
| 36 | Cooper Phillip Rhodes | So | Jackson | 2022 | | 41 | 13 |
| 36 | Seth Benes | Jr | Liberty (Wentzville) | 2022 | | 34 | 13 |
| 41 | Tanner Sears | Sr | Lafayette County | 2018 | | 22 | 12 |
| 41 | Jackson Gross | Jr | Festus | 2021 | | 36 | 12 |
| 43 | Tayler Ross | Sr | Clinton | 2011 | | 25 | 11 |
| 43 | Brian McCoy | | Clinton | 2013 | | 28 | 11 |
| 43 | Drake Matthew Miller | Sr | DeKalb | 2021 | | 16 | 11 |
| 43 | Mason Schirmer | So | Festus | 2022 | | 35 | 11 |
| 43 | Leo Humbert | So | Francis Howell | 2022 | | 42 | 11 |
| 43 | Tytus Cissell | Jr | Francis Howell | 2022 | | 42 | 11 |
| 43 | Caden Reece Bogenpohl | Sr | Jackson | 2022 | | 41 | 11 |
| 50 | Chase Edwards | Sr | Lafayette County | 2017 | | 24 | 10 |
| 50 | Brett Norfleet | Jr | Francis Howell | 2021 | | 42 | 10 |
| 50 | Hayden Cruz Bates | Sr | Festus | 2023 | | 31 | 10 |
| 53 | Tucker Wegener | Sr | Lafayette County | 2015 | | 25 | 9 |
| 54 | Jaden Thacker | Sr | Winona | 2020 | | 17 | 8 |