| Rank | Student | Grade | School | Year | | G | Total |
| 1 | Thomas Frakes | Jr | Portageville | 2021 | | 35 | 47 |
| 2 | Connor S Basler | Sr | Valle Catholic | 2015 | | 36 | 46 |
| 3 | Devrin Weathers | Sr | Webb City | 2020 | | 32 | 44 |
| 4 | Chance Wolfe | Sr | Clever | 2013 | | 27 | 40 |
| 4 | Justin Maloney | Jr | Valley Park | 2017 | | 31 | 40 |
| 4 | Jake McCutcheon | Sr | Francis Howell | 2021 | | 41 | 40 |
| 7 | William Baker | Sr | Hillsboro | 1997 | | 27 | 39 |
| 7 | J. R. Bizzell | Sr | Sikeston | 2005 | | 26 | 39 |
| 9 | Tate Matheny | So | Westminster Christian Academy | 2010 | | 31 | 38 |
| 9 | Connor Earleywine | Jr | Jefferson City | 2020 | | 37 | 38 |
| 11 | Jake Franks | Sr | Nixa | 2000 | | 28 | 37 |
| 11 | Connor Larson | Jr | Westminster Christian Academy | 2011 | | 32 | 37 |
| 11 | Zachary Adams | Sr | Clinton | 2013 | | 28 | 37 |
| 11 | Chase Morris | So | Southern Boone | 2021 | | 36 | 37 |
| 15 | Tyson Shields | Jr | Nixa | 1999 | | 29 | 36 |
| 15 | Ryan Allee | Sr | Westminster Christian Academy | 2011 | | 32 | 36 |
| 15 | Andrew Jones | Sr | Parkway North | 2017 | | 29 | 36 |
| 18 | James Gowin | Sr | Hermitage | 2008 | | 24 | 35 |
| 18 | Connor Einertson | Jr | Westminster Christian Academy | 2011 | | 32 | 35 |
| 18 | Ian Esry | Sr | El Dorado Springs | 2021 | | 25 | 35 |
| 18 | Wyatt Francis Moran | Jr | Plattsburg | 2021 | | 38 | 35 |
| 22 | Tytus Cissell | So | Francis Howell | 2021 | | 42 | 34 |
| 23 | Leo Humbert | Fr | Francis Howell | 2021 | | 42 | 32 |
| 24 | Brian McCoy | | Clinton | 2013 | | 28 | 31 |
| 25 | Jacob Goucher | Sr | Clinton | 2016 | | 22 | 29 |
| 25 | Jackson Lewis | Jr | Plattsburg | 2021 | | 38 | 29 |
| 25 | | Sr | Plattsburg | 2021 | | 37 | 29 |
| 25 | Joseph Hofmeister | Sr | Plattsburg | 2021 | | 37 | 29 |
| 29 | Jakob Yates | Sr | Clinton | 2017 | | 26 | 28 |
| 29 | Cade Beshore | Jr | Nevada | 2021 | | 24 | 28 |