| Rank | Student | Grade | School | Year | | G | AB |
| 1 | Jake McCutcheon | Sr | Francis Howell | 2021 | | 41 | 139 |
| 1 | Tytus Cissell | Jr | Francis Howell | 2022 | | 42 | 139 |
| 3 | Quinton Alexander Borders | Sr | Jackson | 2022 | | 41 | 134 |
| 4 | Brysen Nepute | Jr | Francis Howell | 2021 | | 42 | 132 |
| 5 | | Fr | Francis Howell | 2021 | | 42 | 130 |
| 6 | Brendan Madden | Sr | Vianney | 2014 | | 38 | 126 |
| 7 | Austin Evans | Sr | Southern Boone | 2023 | | 37 | 125 |
| 8 | Derek Abeln | Sr | Hickman | 2017 | | 38 | 124 |
| 8 | Tytus Cissell | So | Francis Howell | 2021 | | 42 | 124 |
| 8 | Brett Norfleet | Sr | Francis Howell | 2022 | | 42 | 124 |
| 11 | Austin Evans | So | Southern Boone | 2021 | | 36 | 123 |
| 11 | Tytus A Cissell | Sr | Francis Howell | 2023 | | 42 | 123 |
| 11 | Macaibe Davis Carter | Jr | Jackson | 2024 | | 38 | 123 |
| 14 | Brett Norfleet | Jr | Francis Howell | 2021 | | 42 | 122 |
| 14 | Leo Humbert | So | Francis Howell | 2022 | | 42 | 122 |
| 16 | Connor Earleywine | Jr | Jefferson City | 2020 | | 37 | 121 |
| 17 | Austin Evans | Jr | Southern Boone | 2022 | | 35 | 119 |
| 18 | Chase Morris | So | Southern Boone | 2021 | | 36 | 117 |
| 19 | | Sr | Jackson | 2024 | | 38 | 116 |
| 19 | Peyton John Kight | Sr | Jackson | 2024 | | 38 | 116 |
| 21 | Kyle Jundt | Jr | Francis Howell | 1997 | | 32 | 115 |
| 21 | Cohen Waldren | Jr | Liberty (Wentzville) | 2023 | | 37 | 115 |
| 23 | Justin Campbell | Jr | Parkway North | 2012 | | 34 | 114 |
| 23 | Connor Faron | Sr | Parkway North | 2012 | | 32 | 114 |
| 23 | Jackson Lewis | Jr | Plattsburg | 2021 | | 38 | 114 |
| 23 | Wyatt Francis Moran | Jr | Plattsburg | 2021 | | 38 | 114 |
| 27 | Conner Larson | Jr | Francis Howell | 2011 | | 32 | 113 |
| 28 | Blake DeWitt | Fr | Sikeston | 2001 | | 28 | 112 |
| 28 | Derek Rallo | Sr | Christian Brothers College | 2010 | | 33 | 112 |
| 28 | Mathew Miller | So | Aurora | 2015 | | 32 | 112 |
| 28 | | Jr | Francis Howell | 2021 | | 42 | 112 |
| 28 | James Brock Steggall | Sr | Plattsburg | 2021 | | 38 | 112 |
| 28 | Adler Kohen Flinn | Jr | Jackson | 2024 | | 38 | 112 |
| 34 | Brett Graves | Sr | Francis Howell | 2003 | | 33 | 111 |
| 34 | Carter Karotka | Sr | Southern Boone | 2021 | | 36 | 111 |
| 36 | Jeff Sargent | So | Francis Howell | 2003 | | 31 | 110 |
| 36 | Josh Street | So | Francis Howell | 2003 | | 31 | 110 |
| 36 | Brett Peel | Sr | Francis Howell | 2011 | | 35 | 110 |
| 36 | Shane Benes | So | Westminster Christian Academy | 2012 | | 32 | 110 |
| 40 | Ryan Allee | Sr | Westminster Christian Academy | 2011 | | 32 | 109 |