| Rank | Student | Grade | School | Year | | G | Total |
| 1 | Jake McCutcheon | Sr | Francis Howell | 2021 | | 41 | 139 |
| 2 | Brysen Nepute | Jr | Francis Howell | 2021 | | 42 | 132 |
| 3 | | Fr | Francis Howell | 2021 | | 42 | 130 |
| 4 | Brendan Madden | Sr | Vianney | 2014 | | 38 | 126 |
| 5 | Derek Abeln | Sr | Hickman | 2017 | | 38 | 124 |
| 5 | Tytus Cissell | So | Francis Howell | 2021 | | 42 | 124 |
| 7 | Austin Evans | So | Southern Boone | 2021 | | 36 | 123 |
| 8 | Brett Norfleet | Jr | Francis Howell | 2021 | | 42 | 122 |
| 9 | Chase Morris | So | Southern Boone | 2021 | | 36 | 117 |
| 10 | Kyle Jundt | Jr | Francis Howell | 1997 | | 32 | 115 |
| 11 | Justin Campbell | Jr | Parkway North | 2012 | | 34 | 114 |
| 11 | Connor Faron | Sr | Parkway North | 2012 | | 32 | 114 |
| 11 | Jackson Lewis | Jr | Plattsburg | 2021 | | 38 | 114 |
| 11 | Wyatt Francis Moran | Jr | Plattsburg | 2021 | | 38 | 114 |
| 15 | Conner Larson | Jr | Francis Howell | 2011 | | 32 | 113 |
| 16 | Blake DeWitt | Fr | Sikeston | 2001 | | 28 | 112 |
| 16 | Derek Rallo | Sr | Christian Brothers College | 2010 | | 33 | 112 |
| 16 | Mathew Miller | So | Aurora | 2015 | | 32 | 112 |
| 16 | James Brock Steggall | Sr | Plattsburg | 2021 | | 38 | 112 |
| 16 | | Jr | Francis Howell | 2021 | | 42 | 112 |
| 21 | Brett Graves | Sr | Francis Howell | 2003 | | 33 | 111 |
| 21 | Carter Karotka | Sr | Southern Boone | 2021 | | 36 | 111 |
| 23 | Jeff Sargent | So | Francis Howell | 2003 | | 31 | 110 |
| 23 | Josh Street | So | Francis Howell | 2003 | | 31 | 110 |
| 23 | Brett Peel | Sr | Francis Howell | 2011 | | 35 | 110 |
| 23 | Shane Benes | So | Westminster Christian Academy | 2012 | | 32 | 110 |
| 27 | Ryan Allee | Sr | Westminster Christian Academy | 2011 | | 32 | 109 |