| Rank | PO | Student | School | Opponent | Date | |
| 1 | 20 | Dillon Myers | Union | New Haven | 4/18/2012 | |
| 2 | 19 | Steven Dillon Hill | Macks Creek | Climax Springs | 5/2/2011 | |
| 2 | 19 | Joseph Cole Register | Macks Creek | | 4/26/2019 | |
| 4 | 18 | Clayton Holt | Savannah | Marshall | 6/2/2012 | |
| 4 | 18 | Clayton Holt | Savannah | Marshall | 6/2/2012 | |
| 4 | 18 | Nathan Bash | Plattsburg | Maryville | 5/12/2022 | |
| 7 | 17 | Kyle Kennedy | Walnut Grove | Dadeville | 5/11/2007 | |
| 7 | 17 | Ben Turner | Westminster Christian Academy | Lutheran North | 4/7/2008 | |
| 7 | 17 | Joseph Cole Register | Macks Creek | | 3/21/2019 | |
| 7 | 17 | Wyatt Francis Moran | Plattsburg | Kingsville | 4/14/2023 | |
| 7 | 17 | Skylar William Wohlers | Osceola | Climax Springs | 4/18/2025 | |
| 12 | 16 | Ron King | Humansville | Spokane | 5/23/1980 | at UMC |
| 12 | 16 | Ron King | Humansville | Spokane | 5/23/1980 | |
| 12 | 16 | Chris Siegel | New Bloomfield | Valley Park | 6/1/1988 | |
| 12 | 16 | Jimmy Smith | Jasper | Marion C. Early | 5/30/2001 | at UMC |
| 12 | 16 | Jimmy Smith | Jasper | Marion C. Early | 5/30/2001 | |
| 12 | 16 | Daniel Anderson | Walnut Grove | Pleasant Hope | 5/6/2004 | |
| 12 | 16 | Kyle Kennedy | Walnut Grove | Wheatland | 3/26/2007 | |
| 12 | 16 | Kyle Kennedy | Walnut Grove | Marion C. Early | 5/5/2007 | |
| 12 | 16 | Luke Tebbe | Walnut Grove | Weaubleau | 4/11/2008 | |
| 12 | 16 | Ben Turner | Westminster Christian Academy | Parkway North | 4/22/2008 | |
| 12 | 16 | Garret Mayo | Advance | Puxico | 4/28/2009 | |
| 12 | 16 | Josh Peck | Walnut Grove | Everton | 3/21/2011 | |
| 12 | 16 | Ryan Lee Cline | Aurora | | 3/16/2018 | |
| 25 | 15 | Claude Warren | Valley Park | New Bloomfield | 6/1/1988 | |
| 25 | 15 | Jay Wallace | Fatima | Senath-Hornersville | 5/30/1991 | |
| 25 | 15 | Crocker | New Bloomfield | North Pemiscot | 5/31/1995 | |
| 25 | 15 | Ryan Lee Cline | Aurora | | 4/10/2018 | |
| 25 | 15 | Ryan Lee Cline | Aurora | | 4/21/2018 | |
| 25 | 15 | Ryan Lee Cline | Aurora | | 7/21/2018 | |
| 25 | 15 | Ryan Lee Cline | Aurora | | 5/15/2018 | |
| 25 | 15 | Hank Woods | Exeter | | 4/9/2018 | |
| 33 | 14 | Cameron Charlton | Macks Creek | Humansville | 4/15/2016 | |