| Rank | Student | School | Opponent | Date | | Inn | SO |
| 1 | Cody Groves | Gideon | Clarkton | 4/5/2012 | | 10 | 25 |
| 2 | Zach Brown | Santa Fe | Wellington-Napoleon | 3/30/2004 | | 9 | 23 |
| 3 | Jesse Mulch | Higbee | Sturgeon | 5/9/2005 | | 10 | 22 |
| 4 | Ryan McCullem | Hickman | Rock Bridge | 5/13/1999 | | 9 | 21 |
| 4 | Brent Moser | Diamond | Purdy | 5/2/2000 | | 9 | 21 |
| 4 | Danny Cowsert | Union | Salem | 3/27/2002 | | 9 | 21 |
| 7 | Jordan Chalden | Missouri Military Academy | Montgomery County | 4/3/1986 | | 9 | 20 |
| 7 | Toby Hartsell | Walnut Grove | Marion C. Early | 5/1/1989 | | 8 | 20 |
| 7 | Kenny McKinley | Hume | Sheldon | 5/19/1996 | | 10 | 20 |
| 7 | Nathan Hughes | Joplin | Glendale | 5/18/2000 | | 9 | 20 |
| 7 | Tyler Hull | New Franklin | La Plata | 5/28/2014 | | | 20 |
| 12 | Levi Marshall | Pleasant Hope | Marion C. Early | 4/4/2023 | | 8.1 | 18 |