| Rank | IP | Student | School | Opponent | Date | |
| 1 | 10 | Dan Hitt | Pattonville | Winnetonka | 6/7/1986 | |
| 1 | 10 | Eric Carpenter | Winnetonka | Pattonville | 6/7/1986 | |
| 1 | 10 | Jamie Johnson | Senath-Hornersville | Fatima | 5/30/1991 | |
| 1 | 10 | Mike Keele | Ritenour | Normandy Collaborative | 5/12/1991 | All in relief |
| 1 | 10 | Jamie Johnson | Senath-Hornersville | Fatima | 5/30/1991 | |
| 1 | 10 | Matt Gilmer | Central (New Madrid County) | Kelly | 5/8/1992 | |
| 1 | 10 | Nick Green | Lawson | North Platte | 5/11/1996 | |
| 1 | 10 | Kenny McKinley | Hume | Sheldon | 5/19/1996 | |
| 1 | 10 | John Hartmann | Westminster Christian Academy | Lutheran South | 4/24/2001 | |
| 1 | 10 | Jay Marshall | John F. Kennedy High School | St. Mary's (St. Louis) | 5/3/2001 | |
| 1 | 10 | Ashton Goudeau | Union | St. Francis Borgia | 5/22/2010 | |
| 12 | 9.1 | Dennis Shanks | Carthage | Clayton | 5/27/1982 | |