| Rank | Student | School | Year | | G | Ast |
| 1 | | Willard | 2020 | | 37 | 331 |
| 2 | | Plattsburg | 2021 | | 38 | 311 |
| 3 | | Hickman | 2017 | | 38 | 277 |
| 3 | | Francis Howell | 2021 | | 42 | 277 |
| 5 | | Francis Howell Central | 2011 | | 35 | 263 |
| 6 | | Westminster Christian Academy | 2006 | | 28 | 254 |
| 7 | | Webb City | 2016 | | 32 | 250 |
| 8 | | Westminster Christian Academy | 2010 | | 31 | 241 |
| 9 | | Westminster Christian Academy | 2011 | | 32 | 233 |
| 10 | | Southern Boone | 2021 | | 36 | 231 |
| 11 | | Webb City | 2020 | | 32 | 226 |
| 12 | | Northwest (Cedar Hill) | 2013 | | 25 | 219 |
| 13 | | Plattsburg | 2022 | | 34 | 218 |
| 14 | | Southern Boone | 2023 | | 37 | 216 |
| 15 | | Northwest (Cedar Hill) | 2014 | | 27 | 214 |
| 16 | | Northwest (Cedar Hill) | 2007 | | 24 | 212 |
| 17 | | Northwest (Cedar Hill) | 2015 | | 24 | 207 |
| 18 | | Northwest (Cedar Hill) | 2006 | | 25 | 204 |
| 18 | | Westminster Christian Academy | 2007 | | 30 | 204 |
| 18 | | Eugene | 2011 | | 25 | 204 |
| 21 | | Scott City | 2023 | | 33 | 203 |