| Rank | Student | School | Year | | G | IP |
| 1 | | Francis Howell | 2021 | | 42 | 280 |
| 2 | | Ft. Zumwalt West | 2017 | | 39 | 267 |
| 3 | | Jackson | 2024 | | 38 | 253 |
| 4 | | Hickman | 2017 | | 38 | 246 |
| 5 | | Plattsburg | 2021 | | 38 | 245 |
| 6 | | Southern Boone | 2021 | | 36 | 240 |
| 7 | | Valle Catholic | 2015 | | 36 | 237 |
| 8 | | Valle Catholic | 2014 | | 35 | 235 |
| 9 | | Parkway North | 2012 | | 34 | 228 |
| 10 | | Francis Howell | 2011 | | 35 | 226.2 |
| 11 | | Ft. Zumwalt South | 2009 | | 34 | 225 |
| 12 | | Webb City | 2021 | | 35 | 224 |
| 13 | | Aurora | 2017 | | 32 | 218 |
| 14 | | Webb City | 2015 | | 32 | 216.1 |
| 15 | | Westminster Christian Academy | 2011 | | 32 | 212.2 |
| 16 | | St. Charles | 2005 | | 30 | 212 |
| 17 | | Liberty (Wentzville) | 2023 | | 37 | 209.2 |
| 18 | | Parkway North | 2003 | | 30 | 206 |
| 19 | | Westminster Christian Academy | 2010 | | 31 | 203.1 |
| 20 | | Scott City | 2023 | | 33 | 202 |
| 21 | | Nixa | 2001 | | 31 | 201.1 |
| 22 | | Tipton | 2023 | | 30 | 198.1 |
| 23 | | Helias Catholic | 2001 | | 29 | 198 |
| 23 | | Westminster Christian Academy | 2009 | | 30 | 198 |
| 25 | | Hickman | 2005 | | 30 | 193 |
| 26 | | Nixa | 2000 | | 28 | 192.1 |
| 27 | | Herculaneum | 2001 | | 29 | 187 |