| Rank | School | Opponent | Date | | Inn | SO |
| 1 | Clever | Billings | 4/19/2022 | | 14 | 31 |
| 2 | Houston | | 3/21/2019 | | 12 | 26 |
| 3 | Hillsboro | Herculaneum | 4/13/1970 | | 11 | 25 |
| 3 | Hume | Sheldon | 5/19/1996 | | 15 | 25 |
| 5 | Missouri Military Academy | Montgomery County | 4/3/1986 | | 9 | 20 |
| 5 | Walnut Grove | Pleasant Hope | 5/4/1989 | | 8 | 20 |
| 5 | Lawson | Kearney | 5/5/1995 | | | 20 |
| 5 | Mid-Buchanan | West Platte | 5/1/1997 | | 10 | 20 |
| 9 | El Dorado Springs | Sherwood | 4/18/2022 | | 8 | 18 |
| 10 | New Bloomfield | Valley Park | 6/1/1988 | | 9 | 16 |
| 10 | New Bloomfield | North Pemiscot | 5/31/1995 | | 8 | 16 |