| Rank | HBP | Student | School | Opponent | Date | |
| 1 | 5 | Trenten Terrill | Summersville | Cabool | 4/15/2025 | |
| 2 | 4 | Mike Davidson | Sweet Springs | Crest Ridge | 4/19/2004 | |
| 2 | 4 | Donny Helm | Greenville | Naylor | 5/7/2004 | |
| 2 | 4 | Kris Irwin | Plato | Norwood | 5/19/2004 | at Fordland |
| 2 | 4 | Ethan Joers | Owensville | Linn | 5/2/2008 | |
| 2 | 4 | Gehlert, Thatcher | Belle | Viburnum | 4/27/2018 | |
| 2 | 4 | Tyler Baer | Tipton | Sacred Heart | 4/26/2021 | |
| 2 | 4 | Wyatt Doyle Jackson | Savannah | Plattsburg | 5/10/2023 | |
| 2 | 4 | Jackson Hoppenthaler | Crest Ridge | Santa Fe | 4/14/2025 | |
| 2 | 4 | Kellen Dean Braden | Nevada | Lamar | 4/16/2026 | |
| 11 | 3 | Jason Bowers | Central (Cape Girardeau) | Hazelwood Central | 6/3/1994 | at UMC |
| 11 | 3 | Jason Bowers | Central (Cape Girardeau) | Hazelwood Central | 6/3/1994 | Class 4A |
| 11 | 3 | Danny Penn | Nevada | Carthage | 5/10/2001 | |
| 11 | 3 | Perry Sewell | Nevada | Aurora | 4/4/2002 | at Carthage |
| 11 | 3 | Drew Martin | Nixa | Liberty (Mountain View) | 4/6/2002 | |
| 11 | 3 | Jacob Talbot | Plato | Dixon | 4/18/2004 | |
| 11 | 3 | Kris Irwin | Plato | Winona | 4/1/2005 | |
| 11 | 3 | Nick Openshaw | Plato | Niangua | 4/15/2005 | |
| 11 | 3 | Spenser Witt | Monett | Republic | 5/11/2009 | |
| 11 | 3 | Michael Ferrera | Westminster Christian Academy | Parkway West | 3/30/2010 | |
| 11 | 3 | Tyler Bennett | Madison | Sturgeon | 3/27/2012 | |
| 11 | 3 | Sam Bash | Plattsburg | Van Horn | 4/14/2018 | |
| 11 | 3 | Trevor Politte | Bismarck | Bourbon | 4/19/2021 | |
| 11 | 3 | Braden Charles Brown | Plattsburg | Sweet Springs | 3/31/2023 | |
| 11 | 3 | Zakariah Allen Kittelson | Plattsburg | West Platte | 5/17/2023 | |
| 11 | 3 | Collin Thomas Kersten | North Platte | North Platte | 3/21/2026 | |