| Rank | Student | School | Opponent | Date | | Inn | R |
| 1 | | Macks Creek | | 4/13/2010 | MC 33, Herm. 28 | 7 | 61 |
| 1 | | Pilot Grove | Northwest (Hughesville) | 4/27/2012 | 35 & 26 | 7 | 61 |
| 3 | | Wellsville | Crossroads College Preparatory | 5/14/2005 | | | 55 |
| 4 | | Gideon | | 9/30/2019 | | 6 | 51 |
| 5 | | Van Buren | Eminence | 5/5/2011 | 48 & 0 | | 48 |
| 6 | | Hermann | Wright City | 4/16/2004 | 25 & 21 | | 44 |
| 7 | | Hallsville | Sturgeon | 4/12/2004 | 34 & 9 | 5 | 43 |
| 7 | | Hermitage | Halfway | 4/30/2008 | 29 & 14 | | 43 |
| 9 | | Mansfield | Ash Grove | 3/23/2000 | | | 42 |
| 9 | | Oak Ridge | Meadow Heights | 4/23/2003 | 24 & 18 | | 42 |
| 11 | | Willard | Mt. Vernon | 4/14/2000 | 33 & 8 | 5 | 41 |
| 11 | | Monett | Purdy | 4/1/2003 | 39 & 2 | 5 | 41 |
| 11 | | Owensville | Linn | 4/21/2009 | 22 & 19 | | 41 |
| 11 | | Walnut Grove | Hermitage | 4/6/2010 | 28 & 13 | | 41 |
| 15 | | St. Clair | Excelsior Springs | 6/5/1999 | | 8 | 33 |
| 15 | | St. Dominic | Notre Dame (Cape Girardeau) | 5/30/2008 | | 7 | 33 |
| 17 | | Liberty | Willard | 6/2/2012 | | 7 | 31 |
| 18 | | Francis Howell | Vianney | 6/3/2011 | | 7 | 27 |
| 19 | | Crystal City | St. Pius X (Kansas City) | 6/1/2000 | | 7 | 26 |
| 20 | | Winnetonka | Kickapoo | 6/1/1985 | | 7 | 25 |