| Rank | Student | School | Opponent | Date | | Inn | R |
| 1 | | Van Buren | Eminence | 5/5/2011 | | | 48 |
| 2 | | Skyline | Walnut Grove | 3/25/2000 | | 5 | 40 |
| 3 | | Monett | Purdy | 4/1/2003 | | 5 | 39 |
| 3 | | New Franklin | Prairie Home | 4/4/2016 | | | 39 |
| 5 | | Licking | Summersville | 4/22/2013 | | | 38 |
| 6 | | Halfway | Walnut Grove | 3/21/2000 | | | 37 |
| 7 | | Beaumont | St. Peter's (Joplin) | 5/25/1950 | at St. Louis | 5 | 36 |
| 8 | | Central (Cape Girardeau) | Notre Dame (Cape Girardeau) | 4/8/1960 | | | 35 |
| 8 | | Mansfield | Niangua | 4/8/1994 | | 3 | 35 |
| 8 | | Steelville | Belle | 3/23/1995 | | | 35 |
| 8 | | Macks Creek | Climax Springs | 4/14/2016 | | 5 | 35 |
| 8 | | Halfway | | 5/7/2018 | vs. Chadwick | 5 | 35 |
| 13 | | Macks Creek | Hermitage | 4/13/2010 | | 7 | 33 |
| 14 | | Exeter | | 3/20/2018 | | 5 | 32 |
| 15 | | Bevier | Brashear | 10/2/2017 | | 5 | 31 |
| 15 | | Plato | | 9/20/2019 | | 5 | 31 |
| 17 | | St. Dominic | Notre Dame (Cape Girardeau) | 5/30/2008 | | 7 | 25 |
| 18 | | Sparta | Sparta | 9/13/2024 | | 7 | 21 |
| 19 | | St. Elizabeth | North Pemiscot | 6/1/1995 | | 6 | 20 |
| 19 | | New Bloomfield | Summit Christian Academy | 6/2/2011 | | 7 | 20 |
| 21 | | St. Clair | Excelsior Springs | 6/5/1999 | | 8 | 19 |
| 21 | | Platte County | St. Mary's (Independence) | 6/1/2002 | | 5 | 19 |