| Rank | Student | School | Opponent | Date | | Inn | Total |
| 1 | | Plato | Newburg | 4/13/2021 | | 5 | 37 |
| 2 | | University Academy Charter | Southeast | 3/28/2022 | | 33353 | 35 |
| 3 | | Dora | Couch | 4/8/2005 | | | 28 |
| 4 | | Hermitage | Macks Creek | 4/4/2009 | | | 25 |
| 5 | | Stoutland | Laquey | 8/31/1998 | | | 24 |
| 5 | | Vienna | Viburnum | 4/17/2014 | | | 24 |
| 5 | | Plato | Newburg | 3/24/2021 | | 3 | 24 |
| 5 | | Hillsboro | Parkway North | 4/17/2023 | | 6 | 24 |
| 5 | | Van-Far | Van-Far | 3/19/2024 | | 3 | 24 |
| 10 | | Windsor | Calhoun | 4/15/2004 | | | 23 |
| 11 | | Hume | Ballard | 5/2/1990 | | | 22 |
| 11 | | Dora | Alton | 4/2/2005 | | | 22 |
| 13 | | Hermitage | Osceola | 4/15/2008 | | | 21 |
| 13 | | Southern Boone | Lexington | 3/25/2023 | | 5 | 21 |
| 15 | | Stoutland | Tuscumbia | 9/21/1999 | | | 20 |
| 15 | | Advance | Richland (Essex) | 4/23/2009 | | | 20 |
| 15 | | Kelly | Central (New Madrid County) | 4/4/2024 | | 5 | 20 |
| 18 | | Advance | Delta | 4/8/2008 | | | 19 |
| 18 | | Hermitage | Macks Creek | 4/14/2009 | | | 19 |
| 18 | | Exeter | | 5/7/2018 | | 6 | 19 |
| 21 | | Southern Boone | | 3/16/2019 | vs. Fulton | 6 | 15 |
| 22 | | Southern Boone | | 4/24/2019 | | 5 | 14 |
| 22 | | Summersville | Newburg | 5/1/2023 | | 5 | 14 |
| 24 | | Kelly | Clearwater | 3/26/2022 | | 5 | 12 |
| 25 | | Carthage | Sullivan | 6/6/1987 | | 7 | 11 |
| 25 | | Oran | Halfway | 6/5/1998 | | 7 | 11 |
| 27 | | Englewood Christian | Oran | 5/20/1981 | | 7 | 9 |
| 28 | | Farmington | Webb City | 6/4/1988 | | 7 | 8 |
| 28 | | St. Vincent | Englewood Christian | 5/31/2000 | | 7 | 8 |