| Rank | Student | School | Opponent | Date | | Inn | RBI |
| 1 | Taylor White | East Prairie | Scott County Central | 5/5/2006 | | 2 | 8 |
| 1 | Cody Rector | Van Buren | Eminence | 5/5/2011 | | 0 | 8 |
| 3 | Dave Beckering | St. Dominic | St. Thomas Aquinas | 4/19/1972 | | 5 | 7 |
| 3 | Jeremy McCoy | Nixa | Ozark | 3/25/1999 | | 6 | 7 |
| 3 | Joe Lincoln | Tipton | Otterville | 4/30/2007 | | 3 | 7 |
| 6 | Jake Whitesides | Hickman | Smith-Cotton | 4/22/1999 | | 4 | 6 |
| 6 | Kyle Smith | Sparta | Niangua | 9/5/2002 | | 2 | 6 |
| 6 | Taylor Thompson | Mansfield | Seymour | 9/14/2004 | | 5 | 6 |
| 6 | Tony Schulte | St. Dominic | Notre Dame (Cape Girardeau) | 5/30/2008 | | 6 | 6 |
| 6 | Ben Catlett | Santa Fe | Green Ridge | 5/8/2008 | | 0 | 6 |
| 6 | Joel Littrell | Owensville | Cuba | 5/7/2009 | | 0 | 6 |
| 6 | Jimmy Layton | Madison | Northeast (Cairo) | 9/23/2017 | | 1 | 6 |