| Rank | Student | School | Opponent | Date | | Inn | RBI |
| 1 | | Central (Cape Girardeau) | Notre Dame (Cape Girardeau) | 4/8/1960 | | | 33 |
| 1 | | Bishop LeBlond | East Buchanan | 5/13/2000 | | | 33 |
| 1 | | Monett | Purdy | 4/1/2003 | | 5 | 33 |
| 4 | | Holden | Sherwood | 4/1/1999 | | | 30 |
| 5 | | Steelville | Belle | 3/23/1995 | | | 28 |
| 5 | | Mansfield | Niangua | 5/3/2000 | | | 28 |
| 7 | | Lawson | Lathrop | 4/27/2001 | | 5 | 27 |
| 8 | | Lawson | North Platte | 4/1/2003 | | 5 | 26 |
| 9 | | St. Dominic | Notre Dame (Cape Girardeau) | 5/30/2008 | Class 3 | 7 | 25 |
| 9 | | St. Dominic | Notre Dame (Cape Girardeau) | 5/30/2008 | at Springfield | 6 | 25 |
| 11 | | Mansfield | Ava | 5/8/2000 | | | 24 |
| 11 | | Lawson | Lathrop | 4/18/2001 | | 5 | 24 |
| 11 | | Sparta | Niangua | 9/5/2002 | | | 24 |
| 11 | | Wellsville | Crossroads College Preparatory | 5/14/2005 | | | 24 |
| 15 | | Parkway North | | 4/2/2019 | @ Ritenour | 3 | 23 |
| 16 | | Parkway North | | 4/12/1999 | | 5 | 21 |
| 17 | | Platte County | St. Mary's (Independence) | 6/1/2002 | Class 3A | 7 | 18 |
| 18 | | Hickman | DeSmet | 6/4/2005 | Class 4 | 7 | 17 |
| 19 | | St. Elizabeth | North Pemiscot | 6/1/1995 | Class 1A | 6 | 16 |
| 19 | | St. Clair | Excelsior Springs | 6/5/1999 | Class 3A | 8 | 16 |
| 19 | | New Bloomfield | Summit Christian Academy | 6/2/2011 | Class 2 | 7 | 16 |