| Rank | Student | School | Opponent | Date | | Inn | HR |
| 1 | | Mansfield | Ava | 5/8/2000 | | | 11 |
| 1 | | Lawson | Lathrop | 5/10/2014 | | | 11 |
| 3 | | Oak Park | Hickman Mills | 5/3/1983 | | | 9 |
| 4 | | Central (Cape Girardeau) | Festus | 4/23/1988 | | | 8 |
| 4 | | Blue Springs | Lee's Summit | 5/28/1998 | | | 8 |
| 4 | | Sparta | Niangua | 9/5/2002 | | | 8 |
| 4 | | Monroe City | Marion County | 5/9/2011 | | | 8 |
| 8 | | Mansfield | Lutie | 4/19/1994 | | | 7 |
| 8 | | Holden | Sherwood | 4/1/1999 | | | 7 |
| 8 | | Parkway Central | St. Charles West | 4/8/1999 | | | 7 |
| 8 | | Mansfield | Hartville | 5/20/1999 | | | 7 |
| 8 | | Jamestown | Harrisburg | 4/28/2000 | | | 7 |
| 8 | | Bishop LeBlond | East Buchanan | 5/13/2000 | | | 7 |
| 8 | | Jamestown | Pilot Grove | 4/25/2002 | 4.5 Innings | | 7 |
| 8 | | Winfield | Community | 5/1/2008 | | | 7 |
| 16 | | Blue Springs | Francis Howell | 6/4/1999 | | 7 | 5 |
| 17 | | Vianney | Francis Howell | 6/3/2011 | | 7 | 4 |
| 18 | | Jennings | Glendale | 6/6/1976 | | 7 | 3 |
| 18 | | Christian Brothers College | Truman | 6/2/1990 | | 7 | 3 |
| 18 | | Blue Springs | Parkway South | 6/5/1999 | | 7 | 3 |
| 18 | | Francis Howell | Vianney | 6/3/2011 | | 7 | 3 |