| Rank | TB | Student | School | Opponent | Date | |
| 1 | 18 | Pete Vitale | Beaumont | St. Peter's (Joplin) | 5/25/1950 | 5 Innings |
| 1 | 18 | Victor Quinn | Liberty (Wentzville) | St. Louis Patriots | 4/3/2021 | 4 HR, 1 2B |
| 3 | 17 | Jake Johnson | Union | St. Francis Borgia | 5/22/2010 | 15 Innings |
| 4 | 16 | Jake Whitesides | Hickman | Smith-Cotton | 4/22/1999 | 4 HR |
| 4 | 16 | Jeremy Haldiman | Jamestown | AC Prep Jr. | 9/14/1999 | |
| 6 | 14 | Dennis Osborne | Ritenour | Riverview Gardens | 5/12/1992 | |
| 7 | 13 | Larry Cattoor | Hillsboro | DeSoto | 4/20/1989 | |
| 7 | 13 | Jamie Rodrigue | St. Clair | Excelsior Springs | 6/5/1999 | at UMC |
| 7 | 13 | Jamie Rodrigue | St. Clair | Excelsior Springs | 6/5/1999 | |
| 7 | 13 | Josh Miljavac | Bishop LeBlond | Lathrop | 4/10/2000 | |
| 7 | 13 | Chris Michael | Clinton | Marshfield | 4/10/2003 | at Buffalo |
| 7 | 13 | Nathan Neel | Windsor | Cole Camp | 4/19/2004 | at Buffalo |
| 7 | 13 | Justin Zimmerman | Union | St. Francis Borgia | 5/22/2010 | |
| 7 | 13 | Trace Ryan Harrington | Republic | Carthage | 4/18/2024 | |
| 15 | 11 | Tom Brewer | Raytown South | Clayton | 5/23/1975 | |
| 15 | 11 | Nick Presko | St. Pius X (Kansas City) | Notre Dame (Cape Girardeau) | 6/3/1999 | |
| 17 | 10 | Phillip Gambill | Licking | Bismarck | 5/31/1989 | |