| Rank | Student | School | Years | | G | Ast |
| 1 | Blake DeWitt | Sikeston | 2001-2004 | | 107 | 235 |
| 2 | Joe Boyer | Hillsboro | 1996-1999 | | 97 | 210 |
| 3 | Logan Rycraft | Mt. Vernon | 2012-2015 | | 95 | 192 |
| 4 | Tony Sargent | Francis Howell | 1999-2001 | | 86 | 185 |
| 5 | Ryan Haverstick | Westminster Christian Academy | 2005-2007 | | 85 | 182 |
| 6 | Brock Allen Miles | Capital City | 2020-2023 | | 117 | 168 |
| 7 | Adam Hanks | Northwest (Cedar Hill) | 2011-2013 | | 80 | 153 |
| 8 | Jackson Lewis | Plattsburg | 2020-2022 | | 92 | 149 |
| 9 | Mark Parker | Hillsboro | 1998-2000 | | 71 | 127 |
| 10 | Luke Tebbe | Walnut Grove | 2008-2011 | | 85 | 123 |
| 11 | Will Baker | Hillsboro | 1994-1997 | | 86 | 118 |
| 12 | Bob Hankins | Hillsboro | 2000-2001 | | 56 | 117 |