| Rank | Student | School | Opponent | Date | | Inn | HR |
| 1 | Tyler Jones (2) and Kyle Smith (2) | Sparta | Niangua | 9/5/2002 | | 2 | 4 |
| 1 | Brent Gremaud, Trent Tiller (2) & Charlie Lowell | Winfield | Community | 5/1/2008 | | 1 | 4 |
| 1 | Austin Flippin, Clark Rohrbach, Garrett Wolfe, & Cole Theissen | Jamestown | Harrisburg | 5/9/2017 | | 2 | 4 |
| 1 | Mustafa White 2, Tyson Strickland, Joseph Carter | University Academy Charter | Northeast (Kansas City) | 3/21/2024 | | 2 | 4 |
| 5 | Chris Dady (2) and Nathan Neel (1) | Windsor | Cole Camp | 4/19/2004 | | 1 | 3 |
| 5 | Tyler Brinkmer, Dane Grunwald and Brian Reller | Winfield | Community | 5/1/2008 | | 3 | 3 |
| 5 | Nolan Korn, Josh Bain, Andrew Young | Northwest (Cedar Hill) | Kirkwood | 4/21/2009 | | 1 | 3 |
| 5 | Caden Bogenpohl, Quinton Borders, Baden Hackworth | Jackson | North County | 3/27/2023 | | 1 | 3 |