| Rank | Student | School | Opponent | Date | | Inn | HR |
| 1 | Dave Beckering | St. Dominic | St. Thomas Aquinas | 4/19/1972 | | 5 | 2 |
| 1 | Russell Brand | Steelville | Belle | 3/27/1997 | | 2 | 2 |
| 1 | Matt Mabe | Steelville | St. James | 4/2/1997 | | 1 | 2 |
| 1 | Jeremy McCoy | Nixa | Ozark | 3/25/1999 | | 6 | 2 |
| 1 | Jake Whitesides | Hickman | Smith-Cotton | 4/22/1999 | | 4 | 2 |
| 1 | Doug Tripp | Mansfield | Ava | 5/8/2000 | | 1 | 2 |
| 1 | Tyler Jones | Sparta | Niangua | 9/5/2002 | | 2 | 2 |
| 1 | Kyle Smith | Sparta | Niangua | 9/5/2002 | | 2 | 2 |
| 1 | Chris Dady | Windsor | Cole Camp | 4/19/2004 | | 1 | 2 |
| 1 | Danny Bryant | Harrisonville | St. Pius X (Kansas City) | 4/28/2004 | | 6 | 2 |
| 1 | Taylor Thompson | Mansfield | Seymour | 9/14/2004 | | 5 | 2 |
| 1 | Joe Lincoln | Tipton | Otterville | 4/30/2007 | | 3 | 2 |
| 1 | Trent Tiller | Winfield | Community | 5/1/2008 | | 1 | 2 |
| 1 | Ben Catlett | Santa Fe | Green Ridge | 5/8/2008 | | 0 | 2 |
| 1 | Joel Littrell | Owensville | Cuba | 5/7/2009 | | 0 | 2 |
| 1 | Paul Martin Zerr | North Callaway | South Callaway | 4/28/2014 | | 3 | 2 |
| 1 | Kyle Grantham | Francis Howell | Lee's Summit West | 6/2/2016 | | 7 | 2 |
| 1 | Jimmy Layton | Madison | Northeast (Cairo) | 9/23/2017 | | 1 | 2 |
| 1 | Mustafa White | University Academy Charter | Northeast (Kansas City) | 3/21/2024 | | 2 | 2 |