| Rank | Student | School | Years | | G | TB |
| 1 | Blake DeWitt | Sikeston | 2001-2004 | | 107 | 349 |
| 2 | Jake Whitesides | Hickman | 1997-2000 | | 100 | 347 |
| 3 | Wyatt Vincent | Nixa | 2021-2024 | | 151 | 303 |
| 4 | Jake Welch | Bernie | 2007-2010 | | 94 | 291 |
| 5 | Nathan Geile | Valle Catholic | 2007-2010 | | 116 | 290 |
| 6 | Jeremy Eierman | Warsaw | 2011-2014 | | 90 | 258 |
| 7 | Ryan Rallo | Christian Brothers College | 1996-1999 | | 97 | 257 |
| 8 | Ryan Mantle | Linn | 2012-2015 | | 91 | 256 |
| 9 | Barry Short | Mansfield | 1989-1992 | | 84 | 254 |
| 10 | Jacob Turner | Westminster Christian Academy | 2006-2009 | | 115 | 249 |
| 11 | Robert Mitchell | Herculaneum | 1998-2001 | | 105 | 244 |
| 12 | Jeff Melton | Herculaneum | 2000-2003 | | 106 | 243 |