| Rank | RBI | Student | School | Opponent | Date | |
| 1 | 14 | Brayden Moore | Saxony Lutheran | Saxony Lutheran | 4/14/2025 | |
| 2 | 13 | Cody Rector | Van Buren | Eminence | 5/5/2011 | |
| 2 | 13 | Jacob Roberts Noland | Kirkwood | Parkway Central | 4/22/2025 | |
| 4 | 11 | Jake Whitesides | Hickman | Smith-Cotton | 4/22/1999 | |
| 4 | 11 | Eric Limanen | Greenville | Omaha (Arkansas) | 3/27/2004 | 5 Innings |
| 4 | 11 | Mason Lewis | Saxony Lutheran | Bloomfield | 3/23/2018 | |
| 7 | 10 | Dave Beckering | St. Dominic | St. Thomas Aquinas | 4/19/1972 | 5 Innings |
| 7 | 10 | Dennis Osborne | Ritenour | Riverview Gardens | 5/12/1992 | |
| 7 | 10 | Thomas Vesely | Plato | Hartville | 4/21/2005 | 5 Innings |
| 7 | 10 | Cory Cantrell | Fair Play | Osceola | 5/10/2021 | 5 Innings |
| 11 | 9 | Jeremy McCoy | Nixa | Ozark | 3/25/1999 | |
| 11 | 9 | Nick Berry | Lawson | East Buchanan | 4/1/2000 | |
| 11 | 9 | Walker Myears | Springfield Catholic | Miller | 4/27/2000 | |
| 11 | 9 | Kevin Altman | Mansfield | Niangua | 5/3/2000 | |
| 11 | 9 | Joe Fabry | St. Paul Lutheran (Concordia) | Windsor | 4/14/2003 | |
| 11 | 9 | Zack Ruesler | Oak Ridge | Meadow Heights | 4/23/2003 | |
| 11 | 9 | Josh Ennis | Jamestown | Bunceton | 9/9/2003 | |
| 11 | 9 | Anthony Martin | Thayer | Eminence | 5/17/2005 | |
| 11 | 9 | Drew Benes | Westminster Christian Academy | Whitfield | 4/8/2006 | |
| 11 | 9 | Travis Henke | Blair Oaks | Van-Far | 4/8/2006 | |
| 11 | 9 | Cale Weeks | Campbell | Cooter | 4/3/2007 | |
| 11 | 9 | Lucas Budo | Northwest (Cedar Hill) | Francis Howell | 5/16/2007 | |
| 11 | 9 | Logan Dollins | Kennett | Poplar Bluff | 3/23/2010 | |
| 11 | 9 | Tyler Ferguson | Southwest (Washburn) | McAuley Catholic | 4/13/2010 | |
| 11 | 9 | Austin Fisher | Winona | Naylor | 5/4/2010 | |
| 11 | 9 | Case Munson | Francis Howell | Vianney | 4/20/2011 | |
| 11 | 9 | Jared Gage | Summit Christian Academy | Butler | 4/10/2012 | |
| 11 | 9 | Chance Wolfe | Clever | Licking | 4/6/2013 | |
| 11 | 9 | Davis Woods | North Callaway HS | Kirksville | 3/19/2022 | |
| 11 | 9 | Trace Ryan Harrington | Republic | Carthage | 4/18/2024 | |
| 31 | 8 | Jamie Rodrigue | St. Clair | Excelsior Springs | 6/5/1999 | Class 3A |
| 32 | 7 | Alex Larkin | St. Dominic | Notre Dame (Cape Girardeau) | 5/30/2008 | Class 3 |
| 32 | 7 | Tony Schulte | St. Dominic | Notre Dame (Cape Girardeau) | 5/30/2008 | Class 3 |