| Rank | School | Opponent | Date | | Inn | R |
| 1 | Dixon | Laquey | 9/10/2024 | | 1 | 38 |
| 2 | North Harrison | Tri-County | 9/10/1992 | | 3 | 24 |
| 3 | Dexter | Richland | 4/8/2010 | | 1 | 22 |
| 4 | Otterville | Prairie Home | 9/21/2002 | (at Boonville) | 2 | 21 |
| 4 | Dixon | Newburg HS | 8/18/2017 | | 1 | 21 |
| 4 | Pleasant Hope | | 4/29/2019 | | 2 | 21 |
| 4 | Holcomb | South Pemiscot | 4/20/2021 | | 1 | 21 |
| 4 | Clearwater | Grandview (Hillsboro) HS | 3/27/2023 | | 1 | 21 |
| 4 | Holcomb | Delta (Deering) | 4/22/2024 | | 1 | 21 |
| 10 | Eureka | Dixon | 10/4/1996 | (at Sullivan) | 1 | 20 |
| 10 | Nixa | Parkview | 8/24/2009 | | 1 | 20 |
| 12 | Russellville | Pilot Grove | 9/21/2020 | | 2 | 19 |
| 12 | Clearwater | Winona | 3/20/2023 | | 1 | 19 |
| 14 | Adrian | Rich Hill | 3/21/2015 | | 2 | 18 |
| 14 | Centralia | | 9/29/2018 | | 2 | 18 |
| 16 | North Harrison | Tri-County | 9/7/1993 | | 1 | 16 |
| 16 | Parkway West | Gateway | 10/2/1998 | | 2 | 16 |
| 16 | Pierce City | | 4/3/2018 | | 1 | 16 |
| 16 | Russellville | | 9/23/2019 | | 4 | 16 |
| 20 | Webster Groves | Parkway North | 9/2/2004 | (at Affton) | 2 | 15 |
| 20 | Nixa | Marshfield | 9/11/2010 | | 4 | 15 |
| 20 | Clearwater | Ellington | 5/3/2022 | | 2 | 15 |
| 23 | Ft. Zumwalt South | Normandy Collaborative | 9/6/1989 | | 1 | 14 |
| 23 | Eureka | Dixon | 10/4/1996 | (at Sullivan) | 3 | 14 |
| 23 | Holt | McCluer | 9/21/2001 | | 2 | 14 |
| 23 | Marion C. Early | Climax Springs | 9/29/2020 | | 1 | 14 |
| 23 | Marion C. Early | Humansville | 10/1/2020 | | 1 | 14 |
| 28 | Highland | Palmyra | 9/25/2023 | | 1 | 13 |
| 28 | Mt. Vernon | Mt. Vernon | 5/22/2023 | | 3 | 13 |
| 28 | Mt. Vernon | Fair Grove | 5/22/2023 | | 3 | 13 |
| 28 | North Point | North Point | 10/2/2025 | | 6 | 13 |
| 32 | Chillicothe | Fatima | 10/29/2022 | | 2 | 10 |
| 32 | Chillicothe | Fatima | 10/29/2022 | | 2 | 10 |
| 32 | Chillicothe | Fatima | 10/29/2022 | Class 3 | 2 | 10 |
| 35 | South Harrison | Montgomery County | 10/31/2025 | | 2 | 9 |
| 36 | Parkway Central | Ft. Zumwalt North | 10/20/1981 | Class 3A-4A | 6 | 8 |
| 37 | St. Elizabeth | Lone Jack | 10/16/2002 | Class 1 | 3 | 7 |
| 38 | Platte County | Notre Dame (Cape Girardeau) | 10/15/2008 | Class 3 | 4 | 6 |
| 38 | Pleasant Hope | Brookfield | 10/20/2012 | Class 2 | 3 | 6 |
| 38 | Bishop LeBlond | South Callaway | 10/26/2013 | Class 2 | 3 | 6 |
| 38 | Kennett | West County | 1/1/2015 | | 6 | 6 |
| 42 | Staley | Marquette | 10/24/2015 | Class 4 | 3 | 5 |