| Rank | R | Student | School | Opponent | Date | |
| 1 | 44 | | Holcomb | Risco | 4/16/2018 | |
| 2 | 41 | | Worth County | North Nodaway | 8/24/2009 | 41 - 29 |
| 3 | 40 | | Central (New Madrid County) | Blytheville (Ark.) | 4/2/2003 | 40-0 (3 inn.) |
| 4 | 38 | | Tri-County | Pattonsburg | 10/1/1999 | |
| 4 | 38 | | Dixon | Laquey | 9/10/2024 | |
| 6 | 37 | | Orrick | Kingsville | 4/21/2021 | |
| 7 | 36 | | Galena | Hollister | 4/8/2003 | |
| 8 | 34 | | Ft. Zumwalt South | Normandy Collaborative | 9/6/1989 | 34-2 |
| 8 | 34 | | Eureka | Dixon | 10/4/1996 | |
| 10 | 33 | | Pattonsburg | Tri-County | 10/1/1999 | 33-38 |
| 10 | 33 | | Dixon | Climax Springs | 10/8/2020 | |
| 10 | 33 | | Holcomb | Clarkton | 3/24/2021 | |
| 13 | 31 | | Ozark | Clever | 9/13/1991 | 31-0 |
| 13 | 31 | | Ozark | Nixa | 9/4/1993 | 31-0 |
| 13 | 31 | | Otterville | Prairie Home | 9/21/2002 | (at Boonville) |
| 16 | 28 | | Holcomb | Delta (Deering) | 4/22/2024 | |
| 17 | 26 | | Dixon | Plato | 9/7/2010 | |
| 17 | 26 | | Dixon | Licking | 4/12/2018 | |
| 17 | 26 | | Dixon | Newburg HS | 9/6/2018 | |
| 20 | 25 | | North Point | North Point | 9/2/2022 | |
| 21 | 22 | | Dixon | Plato | 9/14/2012 | |
| 21 | 22 | | Dixon | Newburg HS | 8/18/2017 | |
| 21 | 22 | | Dixon | Crocker | 10/6/2020 | |
| 21 | 22 | | Chillicothe | Lafayette (St. Joseph) | 9/7/2021 | |
| 21 | 22 | | Chillicothe | Savannah | 9/25/2021 | |
| 26 | 21 | | Novinger | Linn County | 9/19/2025 | |
| 27 | 20 | | Novinger | Grundy County | 10/8/2025 | |
| 28 | 16 | | Southern Boone | Wheaton | 1/1/1981 | Class 1A-2A |
| 28 | 16 | | Parkway Central | Ft. Zumwalt North | 10/20/1981 | Class 3A-4A |
| 28 | 16 | | Fatima | Pleasant Hope | 10/25/2014 | Class 2 |
| 31 | 15 | | Kennett | Crest Ridge | 1/1/2014 | |
| 32 | 14 | | Chillicothe | Fatima | 10/29/2022 | |
| 32 | 14 | | Chillicothe | Fatima | 10/29/2022 | |
| 32 | 14 | | Chillicothe | Fatima | 10/29/2022 | |
| 32 | 14 | | Chillicothe | Fatima | 10/29/2022 | |
| 36 | 13 | | Mt. Vernon | Mt. Vernon | 5/22/2023 | |
| 36 | 13 | | Mt. Vernon | Mt. Vernon | 5/22/2023 | |
| 38 | 12 | | Warrenton | Notre Dame (Cape Girardeau) | 10/24/2015 | Class 3 |
| 39 | 10 | | Staley | Marquette | 10/24/2015 | Class 4 |