| Rank | HR | Student | School | Opponent | Date | |
| 1 | 7 | | Pleasant Hill | Excelsior Springs | 9/13/2011 | |
| 1 | 7 | | Versailles | Osage | 9/30/2020 | |
| 3 | 6 | | Fox | Parkway South | 9/21/2016 | |
| 3 | 6 | | Scott City | Advance | 3/29/2016 | |
| 3 | 6 | | Hillsboro | Fort Zumwalt North | 8/18/2017 | |
| 3 | 6 | | Ozark | Timberland | 9/21/2018 | |
| 3 | 6 | | Buffalo | Seymour | 4/18/2022 | |
| 8 | 5 | | Webb City | Neosho | 9/5/2006 | |
| 8 | 5 | | Nixa | Parkview | 8/24/2009 | |
| 8 | 5 | | Hickman | Ursuline Academy | 9/5/2013 | |
| 8 | 5 | | Fox | Marquette | 9/28/2016 | |
| 8 | 5 | | Hillsboro | St. Dominic | 8/18/2017 | |
| 8 | 5 | | Bernie | | 4/24/2018 | |
| 8 | 5 | | Sullivan | | 9/4/2019 | |
| 8 | 5 | | Chillicothe | Holden | 10/20/2021 | |
| 8 | 5 | | Highland | Westminster Christian Academy | 9/2/2023 | |
| 8 | 5 | | Gallatin | Maysville | 10/14/2023 | |
| 18 | 4 | | Central (New Madrid County) | Blytheville (Ark.) | 4/2/2003 | |
| 18 | 4 | | Webb City | Kickapoo | 9/21/2007 | |
| 18 | 4 | | Kelly | Hillsboro | 9/27/2008 | |
| 18 | 4 | | Nixa | Reeds Spring | 9/28/2009 | |
| 18 | 4 | | Rock Bridge | Hannibal | 9/3/2010 | |
| 18 | 4 | | Nixa | Ozark | 10/8/2010 | |
| 18 | 4 | | Palmyra | Macon | 9/24/2011 | |
| 18 | 4 | | Park Hill South | Central (St. Joseph) | 10/4/2012 | |
| 18 | 4 | | North Platte | East Buchanan | 8/23/2014 | |
| 18 | 4 | | Warrenton | | 1/1/2015 | Class 3 |
| 18 | 4 | | Fox | Pattonville | 9/24/2016 | |
| 18 | 4 | | Seckman | | 9/24/2016 | vs. Festus |
| 18 | 4 | | Sullivan | | 9/19/2019 | vs. St. James |
| 18 | 4 | | Webb City | Seneca | 9/4/2020 | |
| 18 | 4 | | Webb City | Neosho | 9/29/2020 | |
| 18 | 4 | | Webb City | Oak Park | 9/18/2020 | |
| 18 | 4 | | Holcomb | Bernie | 4/13/2021 | |
| 18 | 4 | | Holcomb | Bernie | 4/13/2021 | |
| 18 | 4 | | Lee's Summit West | Parkway South | 10/29/2021 | |
| 18 | 4 | | Lee's Summit West | Parkway South | 10/29/2021 | |
| 18 | 4 | | Kearney | Helias Catholic | 10/28/2022 | |
| 18 | 4 | | Kearney | Helias Catholic | 10/28/2022 | Class 4 |
| 18 | 4 | | Oak Park | Oak Park | 9/23/2024 | |
| 41 | 3 | | Kennett | Crest Ridge | 1/1/2014 | |
| 41 | 3 | | Lathrop | | 1/1/2015 | Class 2 |
| 41 | 3 | | Webb City | Staley | 9/19/2020 | |
| 41 | 3 | | Webb City | Nevada | 9/4/2020 | |
| 41 | 3 | | Webb City | Belton | 9/26/2020 | |
| 41 | 3 | | Chillicothe | Savannah | 9/17/2020 | |
| 41 | 3 | | Mountain Grove | Houston | 4/7/2021 | |
| 41 | 3 | | Chillicothe | Benton | 9/23/2021 | |
| 41 | 3 | | Chillicothe | Lafayette (St. Joseph) | 9/7/2021 | |
| 41 | 3 | | Marceline | Sherwood | 10/30/2021 | Class 2 |
| 41 | 3 | | Highland | South Shelby | 10/3/2023 | |
| 41 | 3 | | Highland | Scotland County | 9/30/2023 | |
| 41 | 3 | | Highland | Clark County | 9/21/2023 | |
| 41 | 3 | | Highland | Brookfield | 9/7/2023 | |
| 55 | 2 | | Seckman | | 1/1/2002 | Class 4 |
| 55 | 2 | | Lee's Summit | | 1/1/2013 | Class 4 |
| 55 | 2 | | Lee's Summit | | 1/1/2014 | Class 4 |
| 55 | 2 | | Fatima | Chillicothe | 10/29/2022 | |
| 55 | 2 | | Carrollton | Chaffee | 10/27/2023 | Class 2 |