| Rank | Student | School | Years | | G | Ast |
| 1 | Maris Ollison | Versailles | 2018-2021 | | 103 | 272 |
| 2 | Jill Gregory | Ozark | 1995-1998 | | 97 | 261 |
| 3 | Olivia Jo Pfeifer | Hannibal | 2014-2017 | | 95 | 259 |
| 4 | Caitlin Chapin | Ozark | 2005-2008 | | 120 | 252 |
| 5 | Maleigh Elizabeth Lemings | Holcomb | 2020-2023 | | 127 | 248 |
| 6 | Debbie Cunningham | Webster Groves | 2004-2007 | | 75 | 245 |
| 7 | Kelsey Harmon | Seckman | 2000-2002 | | 88 | 239 |
| 8 | Joey Smith | Webster Groves | 2012-2015 | | 107 | 233 |
| 9 | Rachel Adams | Seckman | 2000-2002 | | 91 | 232 |
| 10 | Ashley Bolen | Seckman | 1997-2000 | | 112 | 229 |
| 11 | Samantha Lynn Zielinski | Hannibal | 2013-2016 | | 90 | 222 |
| 12 | Molly Carter | Hickman | 2011-2014 | | 105 | 220 |
| 13 | Hailey Presley | Marion C. Early | 2020-2023 | | 123 | 158 |