| Rank | Student | School | Years | | K | IP | Total |
| 1 | Katelyn Tolle | Bevier | 2006-2009 | | 819 | 365.2 | 15.678 |
| 2 | Heather Feltmann | Cor Jesu Academy | 1987-1989 | | 502 | 231 | 15.212 |
| 3 | Emily Fowler-Cornfeld | Clayton | 2002-2004 | | 661 | 319 | 14.505 |
| 4 | Reese Elisabeth Plattner | Archie | 2018-2021 | | 547 | 271 | 14.129 |
| 5 | Taylor Tiffany | Portageville | 2013-2015 | | 1056 | 538 | 13.740 |
| 6 | Paige Bedsworth | Father Tolton Regional Catholic | 2017-2020 | | 1131 | 583 | 13.580 |
| 7 | Abby Summers | West Platte | 2011-2014 | | 1062 | 553 | 13.443 |
| 8 | Jill Wilcoxson | North Harrison | 1994-1997 | | 610 | 320.2 | 13.316 |
| 9 | Katie Shockley | Crocker | 2007-2010 | | 741 | 390.2 | 13.277 |
| 10 | Dava Nelson | North Harrison | 1990-1993 | | 634 | 336 | 13.208 |
| 11 | Valerie Teter | Bevier | 2003-2006 | | 1083 | 580.1 | 13.063 |
| 12 | Lauren Delaney | Helias Catholic | 2002-2005 | | 1096 | 596 | 12.872 |